Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma

被引:48
作者
Chang, Xiubao [1 ]
Zhu, Yuanxiao [1 ]
Shi, Changxin [1 ]
Stewart, A. Keith [1 ]
机构
[1] Mayo Clin Arizona, Mayo Clin, Coll Med, Scottsdale, AZ 85259 USA
关键词
immunomodulatory drugs; multiple myeloma; cancer treatment; cereblon; E3 ubiquitin ligase; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; STEM-CELL TRANSPLANTATION; BORTEZOMIB PLUS DEXAMETHASONE; ENDOTHELIAL GROWTH-FACTOR; INDUCTION TREATMENT PRIOR; MARROW STROMAL CELLS; RAT-LIVER CIRRHOSIS; PIGMENTOSUM GROUP-E; III CLINICAL-TRIAL;
D O I
10.1093/abbs/gmt142
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although immunomodulatory drugs (IMiDs), such as thalidomide, lenalidomide, and pomalidomide, are widely used in the treatment of multiple myeloma (MM), the molecular mechanism of IMiDs' action is largely unknown. In this review, we will summarize recent advances in the application of IMiDs in MM cancer treatment as well as their effects on immunomodulatory activities, anti-angiogenic activities, intervention of cell surface adhesion molecules between myeloma cells and bone marrow stromal cells, anti-inflammatory activities, anti-proliferation, pro-apoptotic effects, cell cycle arrest, and inhibition of cell migration and metastasis. In addition, the potential IMiDs' target protein, IMiDs' target protein's functional role, and the potential molecular mechanisms of IMiDs resistance will be discussed. We wish, by presentation of our naive discussion, that this review article will facilitate further investigation in these fields.
引用
收藏
页码:240 / 253
页数:14
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