ASPERELINES G AND H, TWO NEW PEPTAIBOLS FROM THE MARINE-DERIVED FUNGUS TRICHODERMA ASPERELLUM

被引：16

作者：

Chen, Li ^{[1
,2
]}

Zhong, Ping ^{[1
,2
]}

Pan, Jian-Ru ^{[3
]}

Zhou, Kang-Jing ^{[3
]}

Huang, Kai ^{[1
,2
]}

Fang, Zhe-Xiang ^{[1
,2
]}

Zhang, Qi-Qing ^{[1
,2
,4
]}

机构：

[1] Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Peoples R China

[2] Fuzhou Univ, Coll Chem & Chem Engn, Fuzhou 350002, Peoples R China

[3] Fuzhou Univ, Inst Biotechnol, Coll Biosci & Biotechnol, Fuzhou 350002, Peoples R China

[4] Chinese Acad Med Sci, Peking Union Med Coll, Inst Biomed Engn, Tianjin 300192, Peoples R China

来源：

HETEROCYCLES | 2013年 / 87卷 / 03期

关键词：

Marine-Derived Fungus; Trichoderma asperellum; Crystal; Peptaibol; Aspereline; PEPTAIBIOTICS; ANTIBIOTICS; METABOLITES;

D O I：

10.3987/COM-12-12644

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new peptaibols, asperelines G (1) and H (2), together with five known compounds, asperelines A (3), C (4), D (5), E (6), and F (7) were isolated from the marine-derived fungus Trichoderma asperellum. The structures of these compounds were determined through spectroscopic methods, X-ray diffraction analysis, and chemical derivatization. This study is the first report on asperelines with an acetylated C-terminus and a crystal structure.

引用

页码：645 / 655

页数：11

共 11 条

[1]

Brückner H, 2009, CHEM BIODIVERS, V6, P38, DOI 10.1002/cbdv.200800331

[2] TUMONOIC ACIDS K AND L, NOVEL METABOLITES FROM THE MARINE-DERIVED FUNGUS PENICILLIUM CITRINUM [J].

Chen, Li ;

Huang, Kai ;

Zhong, Ping ;

Hu, Xiao ;

Fang, Zhe-Xiang ;

Wu, Jiu-Lin ;

Zhang, Qi-Qing .

HETEROCYCLES, 2012, 85 (02) :413-419

[3] The occurrence of peptaibols and structurally related peptaibiotics in fungi and their mass spectrometric identification via diagnostic fragment ions [J].

Degenkolb, T ;

Berg, A ;

Gams, W ;

Schlegel, B ;

Gräfe, U .

JOURNAL OF PEPTIDE SCIENCE, 2003, 9 (11-12) :666-678

[4] Trichoderma brevicompactum complex:: Rich source of novel and recurrent plant-protective polypeptide antibiotics (peptaibiotics) [J].

Degenkolb, Thomas ;

Grafenhan, Tom ;

Nirenberg, Helgard I. ;

Gams, Walter ;

Brueckner, Hans .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (19) :7047-7061

[5] Peptaibiotics and peptaibols: An alternative to classical antibiotics? [J].

Duclohier, Herve .

CHEMISTRY & BIODIVERSITY, 2007, 4 (06) :1023-1026

[6]

FUJITA T, 1984, CHEM PHARM BULL, V32, P1822

[7] Peptide antimicrobial agents [J].

Jenssen, Havard ;

Hamill, Pamela ;

Hancock, Robert E. W. .

CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (03) :491-+

[8] Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum [J].

Ren, Jinwei ;

Xue, Chunmei ;

Tian, Li ;

Xu, Minjuan ;

Chen, Jian ;

Deng, Zhiwei ;

Proksch, Peter ;

Lin, Wenhan .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (06) :1036-1044

[9] ANTIBIOTIC PRODUCTION BY MARINE MICROORGANISMS [J].

ROSENFELD, WD ;

ZOBELL, CE .

JOURNAL OF BACTERIOLOGY, 1947, 54 (03) :393-398

[10] Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide A [J].

Rubio, Brent K. ;

Robinson, Sarah J. ;

Avalos, Claudia E. ;

Valeriote, Frederick A. ;

de Voogd, Nicole J. ;

Crews, Phillip .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (08) :1475-1478

← 1 2 →