Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication

被引：15
作者：
Alvarez, Angel L. [1 ]
Habtemariam, Solomon [2 ]
Parra, Francisco [1 ]
机构：
[1] Univ Oviedo, Inst Univ Biotecnol Asturias, Dept Bioquim & Biol Mol, E-33006 Oviedo, Asturias, Spain
[2] Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 24期
关键词：
Bursera simaruba; antiviral; HSV-1; HSV-2; pentacyclic triterpenoids; PHENOLIC-COMPOUNDS; INFECTIONS; BARK;
D O I：
10.1080/14786419.2015.1007456
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The cytotoxicity and antiviral properties of Bursera simaruba against herpes simplex viruses (HSV-1 and HSV-2) were investigated through a bioactivity-guided isolation protocol. The plant material was fractionated using solvent-solvent partitioning, size-exclusion and thin-layer chromatography. The antiviral compounds present in the most active fractions were identified by means of LC-MS and NMR. Three different methods were compared during the evaluation of antiviral activity of samples. Four lupene-related pentacyclic triterpenes were found to be responsible for the anti-herpesvirus effects of B. simaruba and were isolated from this species for the first time. The selective indexes (SI) of B. simaruba-derived samples ranged from 7.7 to 201.9.
引用
收藏
页码：2322 / 2327
页数：6
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