Biochemical, cellular, and pharmacological aspects of the multidrug transporter

被引：1784

作者：

Ambudkar, SV ^{[1
]}

Dey, S

Hrycyna, CA

Ramachandra, M

Pastan, I

Gottesman, MM

机构：

[1] NCI, Cell Biol Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA

[2] NCI, Mol Biol Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 1999年 / 39卷

关键词：

multidrug resistance; P-glycoprotein; drug transport; ATP hydrolysis; cancer chemotherapy; chemosensitizer;

D O I：

10.1146/annurev.pharmtox.39.1.361

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Considerable evidence has accumulated indicating that the multidrug transporter or P-glycoprotein plays a role in the development of simultaneous resistance to multiple cytotoxic drugs in cancer cells. In recent years, various approaches such as mutational analyses and biochemical and pharmacological characterization have yielded significant information about the relationship of structure and function of P-glycoprotein. However, there is still considerable controversy about the mechanism of action of this efflux pump and its function in normal cells. This review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about ifs normal physiological role.

引用

页码：361 / 398

页数：38

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