The Treatment of Minimal Change Disease in Adults

被引：108

作者：

Hogan, Jonathan ^{[1
]}

Radhakrishnan, Jai ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Div Nephrol, New York, NY 10025 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2013年 / 24卷 / 05期

关键词：

CHANGE NEPHROTIC SYNDROME; FOCAL-SEGMENTAL GLOMERULOSCLEROSIS; INTRAVENOUS PULSE CYCLOPHOSPHAMIDE; MYCOPHENOLATE-MOFETIL TREATMENT; PRIMARY GLOMERULAR-DISEASES; LONG-TERM CYCLOSPORINE; SINGLE-DOSE RITUXIMAB; ACUTE-RENAL-FAILURE; STEROID-RESISTANT; CONTROLLED TRIAL;

D O I：

10.1681/ASN.2012070734

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Minimal change disease (MCD) is the etiology of 10%-25% of cases of nephrotic syndrome in adults. The mainstay of treatment for adult MCD, oral gucocorticoids, is based on two randomized controlled trials and extensive observational data in adults, and this treatment leads to remission in over 80% of cases. Relapses are common, and some patients become steroid-resistant (SR), steroid-dependent (SD), or frequently relapsing (FR). The data guiding the treatment of these patients are limited. Here, we review MCD in adults with particular focus on the evidence for immunosuppressive therapy in these patients. J Am Soc Nephrol 24: 702-711, 2013. doi: 10.1681/ASN.2012070734

引用

页码：702 / 711

页数：10

共 89 条

[1]

ABRAMOWI.M, 1970, LANCET, V1, P959

[2]

ALKHADER AA, 1979, CLIN NEPHROL, V11, P26

[3] Induction of remission following a single dose of rituximab alone in a patient with minimal change nephrotic syndrome [J].

Amemiya, Nobuyuki ;

Takei, Takashi ;

Kojima, Chiari ;

Nokiba, Hirohiko ;

Itabashi, Mitsuyo ;

Nitta, Kosaku .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2011, 15 (06) :933-936

[4]

[Anonymous], 2012, KIDNEY INT S, V2, P183

[5] T regulatory cell function in idiopathic minimal lesion nephrotic syndrome [J].

Araya, Carlos ;

Diaz, Leila ;

Wasserfall, Clive ;

Atkinson, Mark ;

Mu, Wei ;

Johnson, Richard ;

Garin, Eduardo .

PEDIATRIC NEPHROLOGY, 2009, 24 (09) :1691-1698

[6] Upregulation of Nuclear Factor-Related Kappa B Suggests a Disorder of Transcriptional Regulation in Minimal Change Nephrotic Syndrome [J].

Audard, Vincent ;

Pawlak, Andre ;

Candelier, Marina ;

Lang, Philippe ;

Sahali, Djillali .

PLOS ONE, 2012, 7 (01)

[7]

Baglio V, 2006, J NEPHROL, V19, P819

[8] Intravenous cyclophosphamide in steroid-resistant nephrotic syndrome [J].

Bajpai, A ;

Bagga, A ;

Hari, P ;

Dinda, A ;

Srivastava, RN .

PEDIATRIC NEPHROLOGY, 2003, 18 (04) :351-356

[9] CONTROLLED TRIAL OF AZATHIOPRINE IN TREATMENT OF STEROID-RESPONSIVE NEPHROTIC SYNDROME OF CHILDHOOD [J].

BARRATT, TM ;

CAMERON, JS ;

CHANTLER, C ;

COUNAHAN, R ;

OGG, CS ;

SOOTHILL, JF .

ARCHIVES OF DISEASE IN CHILDHOOD, 1977, 52 (06) :462-463

[10]

Beco A, 2010, CLIN NEPHROL, V74, P308

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