Isatin hybrids and their anti-tuberculosis activity

被引：237
作者：
Xu, Zhi [1 ]
Zhang, Shu [2 ]
Gao, Chuan [3 ]
Fan, Jing [4 ]
Zhao, Feng [3 ]
Lv, Zao-Sheng [1 ]
Feng, Lian-Shun [1 ,3 ,5 ]
机构：
[1] Wuhan Univ Sci & Technol, Wuhan 430081, Peoples R China
[2] Pony Testing Int Grp, Wuhan 430034, Peoples R China
[3] WuXi AppTec, Wuhan 430075, Peoples R China
[4] Hengshui Univ, Hengshui 053000, Peoples R China
[5] Peking Univ, Synthet & Funct Biomol Ctr, Beijing 100871, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 02期
关键词：
Isatin hybrids; Mycobacterium tuberculosis; Quinolone; Structure-activity relationship; Review; VITRO ANTIMYCOBACTERIAL ACTIVITY; MYCOBACTERIUM-TUBERCULOSIS; MOLECULAR HYBRIDIZATION; MANNICH-BASES; ANTI-HIV; DERIVATIVES; DESIGN; ANALOGS; ANTIBACTERIAL; ANTIMALARIAL;
D O I：
10.1016/j.cclet.2016.07.032
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tuberculosis (TB) is one of the most common and even fatal infectious diseases known to mankind. Millions of new cases are reported every year over the world, and one-third of the world's population is potentially infected with mycobacteria tuberculosis (MTB). Research to develop novel anti-TB drugs led to the identification of several isatin-based antimycobacterial agents, among which a number of potential candidates displayed excellent antimycobacterial activity and were found to be free of cytotoxicity. This review outlines the advances in the application of isatin hybrids as antimycobacterial agents and the critical aspects of design and structure-activity relationship of these derivatives. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
引用
收藏
页码：159 / 167
页数：9
相关论文
共 44 条
[1]   Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH) [J].
Aboul-Fadl, T ;
Mohammed, FAH ;
Hassan, EAS .
ARCHIVES OF PHARMACAL RESEARCH, 2003, 26 (10) :778-784
[2]   Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building [J].
Aboul-Fadl, Tarek ;
Bin-Jubair, Fayzah A. S. ;
Aboul-Wafa, Omima .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (10) :4578-4586
[3]   Design, synthesis and in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antitubercular and antimalarial agents [J].
Akhaja, Tarunkumar Nanjibhai ;
Raval, Jignesh Priyakant .
CHINESE CHEMICAL LETTERS, 2012, 23 (07) :785-788
[4]   Design, synthesis, in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antibacterial, antifungal and anti-tubercular agents [J].
Akhaja, Tarunkumar Nanjibhai ;
Raval, Jignesh Priyakant .
CHINESE CHEMICAL LETTERS, 2012, 23 (04) :446-449
[5]   1,3-dihydro-2H-indol-2-ones derivatives: Design, Synthesis, in vitro antibacterial, antifungal and antitubercular study [J].
Akhaja, Tarunkumar Nanjibhai ;
Raval, Jignesh Priyakant .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (11) :5573-5579
[6]  
Arul K, 2014, INT J PHARM PHARM SC, V6, P506
[7]   Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives [J].
Bal, TR ;
Anand, B ;
Yogeeswari, P ;
Sriram, D .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (20) :4451-4455
[8]   Novel isatinyl thiosemicarbazones derivatives as potential molecule to combat HIV-TB co-infection [J].
Banerjee, Debjani ;
Yogeeswari, Perumal ;
Bhat, Pritesh ;
Thomas, Anisha ;
Srividya, Madala ;
Sriram, Dharmarajan .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (01) :106-121
[9]   Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice [J].
Bermudez, LE ;
Reynolds, R ;
Kolonoski, P ;
Aralar, P ;
Inderlied, CB ;
Young, LS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (08) :2685-2687
[10]   Synthesis and antimycobacterial activity of new S-alkylisothiosemicarbazone derivatives [J].
Cocco, MT ;
Congiu, C ;
Onnis, V ;
Pellerano, ML ;
De Logu, A .
BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (03) :501-506
12345