Standardised Mangifera indica extract is an ideal antioxidant

被引：93

作者：

Ling, Lai Teng ^{[2
]}

Yap, Su-Ann ^{[1
]}

Radhakrishnan, Ammu K. ^{[1
]}

Subramaniam, Thavamanithevi ^{[3
]}

Cheng, Hwee Ming ^{[2
]}

Palanisamy, Uma D. ^{[4
]}

机构：

[1] Int Med Univ, Fac Med & Hlth, Dept Pathol, Kuala Lumpur 57000, Malaysia

[2] Univ Malaya, Fac Med, Dept Physiol, Kuala Lumpur 50603, Malaysia

[3] SIRIM Berhad, Biocosmet & Nat Prod Programme, Shah Alam 40911, Selangor, Malaysia

[4] Monash Univ, Sch Med & Hlth Sci, Bandar Sunway 46150, Selangor Darul, Malaysia

来源：

FOOD CHEMISTRY | 2009年 / 113卷 / 04期

关键词：

Apoptosis; Free radical scavenging; Lipid peroxidation; Mangifera indica; Mangiferin; Pro-oxidant; Oxidant-induced cell death; L; EXTRACT;

D O I：

10.1016/j.foodchem.2008.09.004

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The standardised ethanolic and aqueous extracts of Mangifera indica leaf were prepared and analysed for their free radicals scavenging activity. The IC50 values using the DPPH assay were 0.17 +/- 0.02 and 0.49 +/- 0.4 mg/ml, respectively. Standardised ethanolic extracts of the R indica leaf had a solid content of 9.1 +/- 0.7%, mangiferin concentration of 73 +/- 0.17 mg/g of dry weight of the extract, free radical scavenging activity (IC50) of 0.1 7 +/- 0.02 mg/ml and total phenolic content of 590 +/- 48 mg/g of extract. The protection exhibited by these extracts against lipid peroxidation Was Superior to butylated hydroxytoluene (BHT) and commercial grape seed extract. These extracts at higher concentration did not exhibit pro-oxidant activities when compared to vitamin C. Our findings also show that the aqueous and ethanolic extracts of M. indica leaf protect NIH/3T3 cells from oxidant-induced cell death. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1154 / 1159

页数：6

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