This study sought to examine how performance aspects of human resources (selection, training, worker mobility, job security, job design, rewards, assessment of results and participation) communicate and impact on corporate entrepreneurship (risk-taking activities, pioneering, high innovation, and aggressive competition) with respect to the role of procedural justice and organizational citizenship behavior. This study shows that high performance of human resources has a positive relation with corporate entrepreneurship. Data analysis is done through collecting questionnaire from 93 managers of small and medium enterprises in Gilan using Pierson statistical test and multiple regressions. Research findings indicate that human resources are important for corporate Entrepreneurship prevalence and reach to a competitive power and maintain corporate development in a Long-term. In this regard, Procedural justice and organizational citizenship behavior is effective in corporate development in long-term and finally some practical solutions are listed for achieving the desired goal. [Ali Atashi, Hossein kharabi. Effect of high-performance human resource management in the corporate entrepreneurship. Life Sci J 2012; 9(4):1341-1353] (ISSN:1097-8135). http://www.lifesciencesite.com. 203