Synthesis of Tetrasubstituted Pyrroles from Terminal Alkynes and Imines

被引：45

作者：

Hu, Yancheng ^{[1
]}

Wang, Chunxiang ^{[1
]}

Wang, Dongping ^{[1
]}

Wu, Fan ^{[1
]}

Wan, Boshun ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 12期

关键词：

H BOND FUNCTIONALIZATION; POLYSUBSTITUTED PYRROLES; 3-COMPONENT SYNTHESIS; ONE-POT; AEROBIC SYNTHESIS; C-C; REARRANGEMENT; ADDITIONS; ALCOHOLS; FURANS;

D O I：

10.1021/ol401369d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrasubstituted pyrroles can be obtained via the reaction of terminal alkynes and Imines using (BuLi)-Bu-n as the base In one step with high chemoselectivity (method 1). Alternatively, the intermediate propargylamines can also react with imines to afford tetrasubstituted pyrroles when using LiHMDS as the base (method 2), which provides a complementary method to construct the pyrroles with different substituents.

引用

页码：3146 / 3149

页数：4

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