High-Grade Cervical Disease in Adolescents With HIV

被引：4

作者：

Massad, L. Stewart ^{[1
]}

Evans, Charlesnika T. ^{[2
]}

D'Souza, Gypsyamber ^{[3
]}

Darragh, Teresa ^{[4
]}

Minkoff, Howard ^{[5
]}

Henry, Donna ^{[6
]}

Goparaju, Lakshm ^{[7
]}

Muderspach, Laila I. ^{[8
]}

Watts, D. Heather ^{[9
]}

机构：

[1] Washington Univ, Sch Med, Div Gynecol & Oncol, St Louis, MO 63110 USA

[2] Univ Illinois, Sch Publ Hlth, Chicago, IL USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[4] Univ Calif San Francisco, San Francisco, CA 94143 USA

[5] Malmonides Med Ctr, Brooklyn, NY USA

[6] Montefiore Med Ctr, Bronx, NY 10467 USA

[7] Georgetown Univ, Washington, DC USA

[8] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[9] NICHHD, Bethesda, MD 20892 USA

来源：

JOURNAL OF LOWER GENITAL TRACT DISEASE | 2008年 / 12卷 / 03期

关键词：

HPV; adolescents; cervical cancer prevention; Pap test; HIV in women;

D O I：

10.1097/LGT.0b013e318160b9a5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective. To estimate the risk of high-grade squamous intraepithelial lesions (HSIL) in adolescents with HIV. Materials and Methods. Review of cervical cytology and biopsy results from women aged 20 years and younger obtained within 3 years of enrollment in a prospective multicenter study. Results. At enrollment, none of 132 adolescent participants (45 HIV seropositive and 87 seronegative) had HSIL or cervical intraepithelial neoplasia grade 2 or 3 (CIN 2,3). Eight (7%) of 123 women with follow-up developed highgrade disease after a median of 2.6 years of observation. The incidence of HSIL/CIN 2,3 was 2.7/100 person-years (4.8/100 person-years in HIV seropositive and 1.6/100 person-years in HIV seronegative women; relative risk = 3.1; 95% CI = 0.76-12.74; p = .13). No cancers were found in adolescents during the study. Conclusions. The low incidence of HSIL or CIN 23 in adolescents suggests that optimal management is careful observation rather than preventive treatment of low-grade abnormalities.

引用

页码：199 / 203

页数：5

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