3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

被引：50

作者：

Hendricks, Robert T. ^{[1
]}

Spencer, Stacey R. ^{[2
]}

Blake, James F. ^{[2
]}

Fell, Jay B. ^{[2
]}

Fischer, John P. ^{[2
]}

Stengel, Peter J. ^{[2
]}

Leveque, Vincent J. P. ^{[1
]}

LePogam, Sophie ^{[1
]}

Rajyaguru, Sonal ^{[1
]}

Najera, Isabel ^{[1
]}

Josey, John A. ^{[2
]}

Swallow, Steven ^{[1
]}

机构：

[1] Roche Palo Alto LLC, Med Chem, Palo Alto, CA 94304 USA

[2] Array BioPharma Inc, Boulder, CO 80301 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 02期

关键词：

HCV; NS5b; rdrp; Gamess; Polymerase; Hepatitis; Inhibitor; Non-nucleoside; Palm; Isoquinoline; 3-Hydroxyisoquinoline; Replicon; Dioxo-benzoisothiazole; Negishi; Suzuki; 2-Aminobenzenesulfonamide; N-tert-Butyl-2-chlorobenzene-sulfonamide; 3-Carbomethoxy-1,2,3,4-tetrahydroisoquinoline-1,4-dione; Computational; Model; Conformation; HEPATITIS-C VIRUS;

D O I：

10.1016/j.bmcl.2008.11.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：410 / 414

页数：5

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