Erythropoietin in cancer: a dilemma in risk therapy

被引：35
作者：
Cao, Yihai [1 ,2 ]
机构：
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden
[2] Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 04期
基金：
欧洲研究理事会; 瑞典研究理事会;
关键词：
angiogenesis; cancer therapy; erythropoietin; erythropoiesis; anemia; RECOMBINANT-HUMAN-ERYTHROPOIETIN; TUMOR-NECROSIS-FACTOR; ENDOTHELIAL GROWTH-FACTOR; ERYTHROPOIETIN/ERYTHROPOIETIN-RECEPTOR SYSTEM; STIMULATING AGENTS; PDGF-BB; BEARING MICE; MODULATES ERYTHROPOIESIS; CELL DISSEMINATION; RENAL-CARCINOMA;
D O I：
10.1016/j.tem.2012.10.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Erythropoietin (EPO) is a frequently prescribed drug for treatment of cancer-related and chemotherapy-induced anemia in cancer patients. Paradoxically, recent preclinical and clinical studies indicate that EPO could potentially accelerate tumor growth and jeopardize survival in cancer patients. In this review I critically discuss the current knowledge and broad biological functions of EPO in association with tumor growth, invasion, and angiogenesis. The emphasis is focused on discussing the complex interplay between EPO and other tumor-derived factors in angiogenesis, tumor growth, invasion, and metastasis. Understanding the multifarious functions of EPO and its reciprocal relation with other signaling pathways is crucial for developing more effective agents for cancer therapy and for minimizing risks for cancer patients.
引用
收藏
页码：190 / 199
页数：10
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