Asymmetric Chiral Ligand-Directed Alkene Dioxygenation

被引：53

作者：

Neufeldt, Sharon R. ^{[1
]}

Sanford, Melanie S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 01期

关键词：

CATALYZED INTRAMOLECULAR CHLOROAMINATION; N-FLUOROBENZENESULFONIMIDE; UNACTIVATED ALKENES; PALLADIUM; DIAMINATION; OXIDATION; DIACETOXYLATION; DIFUNCTIONALIZATION; AMINOACETOXYLATION; FUNCTIONALIZATION;

D O I：

10.1021/ol303003g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.

引用

页码：46 / 49

页数：4

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