Asymmetric Chiral Ligand-Directed Alkene Dioxygenation

被引：53
|
作者：
Neufeldt, Sharon R. [1 ]
Sanford, Melanie S. [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 01期
关键词：
CATALYZED INTRAMOLECULAR CHLOROAMINATION; N-FLUOROBENZENESULFONIMIDE; UNACTIVATED ALKENES; PALLADIUM; DIAMINATION; OXIDATION; DIACETOXYLATION; DIFUNCTIONALIZATION; AMINOACETOXYLATION; FUNCTIONALIZATION;
D O I：
10.1021/ol303003g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.
引用
收藏
页码：46 / 49
页数：4
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