Wound Modulation After Filtration Surgery

被引：130

作者：

Seibold, Leonard K. ^{[1
]}

Sherwood, Mark B. ^{[2
]}

Kahook, Malik Y. ^{[1
]}

机构：

[1] Univ Colorado Denver, Rocky Mt Lions Eye Inst, Dept Ophthalmol, Aurora, CO 80045 USA

[2] Univ Florida, Coll Med, Dept Ophthalmol, Gainesville, FL 32610 USA

来源：

SURVEY OF OPHTHALMOLOGY | 2012年 / 57卷 / 06期

关键词：

filtration surgery; glaucoma; trabeculectomy; wound healing; wound modulation; GLAUCOMA FILTERING SURGERY; TENONS CAPSULE FIBROBLASTS; ENDOTHELIAL GROWTH-FACTOR; INTRAOPERATIVE MITOMYCIN-C; OPEN-ANGLE GLAUCOMA; INDUCED MYOFIBROBLAST TRANSDIFFERENTIATION; ANTI-SCARRING AGENT; 5-YEAR FOLLOW-UP; AQUEOUS-HUMOR; NEOVASCULAR GLAUCOMA;

D O I：

10.1016/j.survophthal.2012.01.008

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Filtration surgery is the standard invasive procedure for the management of intraocular pressure in advanced glaucoma. The key to a successful outcome is to modulate the normal wound healing cascade that leads to closure of the newly created aqueous outflow pathway. Antifibrotic agents such as mitomycin C and 5-fluorouracil have been increasingly used to modulate the wound healing process and increase surgical success. Although these agents have proven efficacy, they also increase the risk of complications. Efforts have centered on the identification of novel agents and techniques that can influence wound modulation without these complications. We detail new agents and methods under investigation to control wound healing after filtration surgery. (Surv Ophthalmol 57:530-550, 2012. (c) 2012 Elsevier Inc. All rights reserved.)

引用

页码：530 / 550

页数：21

共 161 条

[1] Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β [J].

Abreu, JG ;

Ketpura, NI ;

Reversade, B ;

De Robertis, EM .

NATURE CELL BIOLOGY, 2002, 4 (08) :599-604

[2] Phase 1 Study of Anti-CTGF Monoclonal Antibody in Patients with Diabetes and Microalbuminuria [J].

Adler, Sharon G. ;

Schwartz, Sherwyn ;

Williams, Mark E. ;

Arauz-Pacheco, Carlos ;

Bolton, Warren K. ;

Lee, Tyson ;

Li, Dongxia ;

Neff, Thomas B. ;

Urquilla, Pedro R. ;

Sewell, K. Lea .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 5 (08) :1420-1428

[3] Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs [J].

Aigner, A .

JOURNAL OF BIOTECHNOLOGY, 2006, 124 (01) :12-25

[4] Suramin modulates wound healing of rabbit conjunctiva after trabeculectomy:: Comparison with mitomycin C [J].

Akman, A ;

Bilezikçi, C ;

Demirhan, B ;

Aydin, P .

CURRENT EYE RESEARCH, 2003, 26 (01) :37-43

[5] Scleromalacia following trabeculectomy with intraoperative mitomycin C [J].

Akova, YA ;

Koç, F ;

Yalvaç, I ;

Duman, S .

EUROPEAN JOURNAL OF OPHTHALMOLOGY, 1999, 9 (01) :63-65

[6]

[Anonymous], 1996, Am J Ophthalmol, V121, P349

[7] A ten-year follow-up up on a prospective, randomized trial of postoperative corticosteroids after trabeculectomy [J].

Araujo, SV ;

Spaeth, GL ;

Roth, SM ;

Starita, RJ .

OPHTHALMOLOGY, 1995, 102 (12) :1753-1759

[8] SYNERGISTIC EFFECT OF VASCULAR ENDOTHELIAL GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR ON ANGIOGENESIS IN-VIVO [J].

ASAHARA, T ;

BAUTERS, C ;

ZHENG, LP ;

TAKESHITA, S ;

BUNTING, S ;

FERRARA, N ;

SYMES, JF ;

ISNER, JM .

CIRCULATION, 1995, 92 (09) :365-371

[9]

Azuara-Blanco A, 1999, OPHTHALMIC SURG LAS, V30, P126

[10] Production and characterization of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen [J].

Barnes, CS ;

Krafft, B ;

Frech, M ;

Hofmann, UR ;

Papendieck, A ;

Dahlems, U ;

Gellissen, G ;

Hoylaerts, MF .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2001, 27 (04) :337-347

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