Metabolic Signaling to Chromatin

被引：92

作者：

Berger, Shelley L. ^{[1
,2
]}

Sassone-Corsi, Paolo ^{[3
]}

机构：

[1] Univ Penn, Dept Biol, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Genet, Epigenet Program, Philadelphia, PA 19104 USA

[3] Univ Calif Irvine, Dept Biol Chem, Ctr Epigenet & Metab, Irvine, CA 92697 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2016年 / 8卷 / 11期

关键词：

MAMMALIAN CIRCADIAN CLOCK; LIFE-SPAN EXTENSION; ADP-RIBOSE POLYMERS; ATP-CITRATE LYASE; REV-ERB-ALPHA; GENE-EXPRESSION; HISTONE ACETYLATION; CALORIE RESTRICTION; CELLULAR SENESCENCE; GENOMIC INSTABILITY;

D O I：

10.1101/cshperspect.a019463

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is a dynamic interplay between metabolic processes and gene regulation via the remodeling of chromatin. Most chromatin-modifying enzymes use cofactors, which are products of metabolic processes. This article explores the biosynthetic pathways of the cofactors nicotinamide adenine dinucleotide (NAD), acetyl coenzyme A (acetyl-CoA), S-adenosyl methionine (SAM), alpha-ketoglutarate, and flavin adenine dinucleotide (FAD), and their role in metabolically regulating chromatin processes. A more detailed look at the interaction between chromatin and the metabolic processes of circadian rhythms and aging is described as a paradigm for this emerging interdisciplinary field.

引用

页数：23

共 160 条

[1] Cycles in spatial and temporal chromosomal organization driven by the circadian clock [J].

Aguilar-Arnal, Lorena ;

Hakim, Ofir ;

Patel, Vishal R. ;

Baldi, Pierre ;

Hager, Gordon L. ;

Sassone-Corsi, Paolo .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 20 (10) :1206-+

[2] KAT(ching) Metabolism by the Tail: Insight into the Links between Lysine Acetyltransferases and Metabolism [J].

Albaugh, Brittany N. ;

Arnold, Kevin M. ;

Denu, John M. .

CHEMBIOCHEM, 2011, 12 (02) :290-298

[3] Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology [J].

Alenghat, Theresa ;

Meyers, Katherine ;

Mullican, Shannon E. ;

Leitner, Kirstin ;

Adeniji-Adele, Adetoun ;

Avila, Jacqueline ;

Bucan, Maja ;

Ahima, Rexford S. ;

Kaestner, Klaus H. ;

Lazar, Mitchell A. .

NATURE, 2008, 456 (7224) :997-U88

[4] Stem cells and reprogramming: breaking the epigenetic barrier? [J].

Ang, Yen-Sin ;

Gaspar-Maia, Alexandre ;

Lemischka, Ihor R. ;

Bernstein, Emily .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2011, 32 (07) :394-401

[5] Nuclear-Cytoplasmic Localization of Acetyl Coenzyme A Synthetase-1 in the Rat Brain [J].

Ariyannur, Prasanth S. ;

Moffett, John R. ;

Madhavarao, Chikkathur N. ;

Arun, Peethambaran ;

Vishnu, Nisha ;

Jacobowitz, David M. ;

Hallows, William C. ;

Denu, John M. ;

Namboodiri, Aryan M. A. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2010, 518 (15) :2952-2977

[6] SIRT1 regulates circadian clock gene expression through PER2 deacetylation [J].

Asher, Gad ;

Gatfield, David ;

Stratmann, Markus ;

Reinke, Hans ;

Dibner, Charna ;

Kreppel, Florian ;

Mostoslavsky, Raul ;

Alt, Frederick W. ;

Schibler, Ueli .

CELL, 2008, 134 (02) :317-328

[7] Histone Modifications and Cancer [J].

Audia, James E. ;

Campbell, Robert M. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2016, 8 (04)

[8] The Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis [J].

Austenaa, Liv ;

Barozzi, Iros ;

Chronowska, Agnieszka ;

Termanini, Alberto ;

Ostuni, Renato ;

Prosperini, Elena ;

Stewart, A. Francis ;

Testa, Giuseppe ;

Natoli, Gioacchino .

IMMUNITY, 2012, 36 (04) :572-585

[9] PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation [J].

Bai, Peter ;

Canto, Caries ;

Oudart, Hugues ;

Brunyanszki, Attila ;

Cen, Yana ;

Thomas, Charles ;

Yamamoto, Hiroyasu ;

Huber, Aline ;

Kiss, Borbala ;

Houtkooper, Riekelt H. ;

Schoonjans, Kristina ;

Schreiber, Valerie ;

Sauve, Anthony A. ;

Menissier-de Murcia, Josiane ;

Auwerx, Johan .

CELL METABOLISM, 2011, 13 (04) :461-468

[10] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [J].

Baker, Darren J. ;

Wijshake, Tobias ;

Tchkonia, Tamar ;

LeBrasseur, Nathan K. ;

Childs, Bennett G. ;

van de Sluis, Bart ;

Kirkland, James L. ;

van Deursen, Jan M. .

NATURE, 2011, 479 (7372) :232-U112

← 1 2 3 4 5 6 7 8 9 10 →