Animal models of chronic kidney disease: useful but not perfect

被引：115

作者：

Becker, Gavin J. ^{[1
]}

Hewitson, Tim D.

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Dept Nephrol, Melbourne, Vic 3050, Australia

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2013年 / 28卷 / 10期

关键词：

chronic kidney disease; animal models; RENAL TUBULOINTERSTITIAL FIBROSIS; NONHUMAN PRIMATE MODELS; DIABETIC-NEPHROPATHY; MEMBRANOUS NEPHROPATHY; URETERAL OBSTRUCTION; RHESUS MACAQUES; TRANSGENIC MICE; MOUSE MODELS; INJURY; NEPHRITIS;

D O I：

10.1093/ndt/gft071

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Animal models of chronic kidney disease (CKD) approximate the human condition and are keys to understanding its pathogenesis and to developing rational treatment strategies. The ethical use of animals requires a detailed understanding of the strengths and limitations of each species and the disease model, and the way in which findings can be translated from animals to humans. While not perfect, the careful use of animal experiments offers the opportunity to examine individual mechanisms in an accelerated time frame.

引用

页码：2432 / 2438

页数：7

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