Atopic keratoconjunctivitis: A review

被引:107
作者
Chen, Joseph J. [1 ]
Applebaum, Danielle S. [2 ]
Sun, Grace S. [2 ]
Pflugfelder, Stephen C. [1 ]
机构
[1] Baylor Coll Med, Dept Ophthalmol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA
关键词
atopic dermatitis; atopic keratoconjunctivitis; conjunctiva; cornea; keratoconus; ocular; sight threatening; ALLERGIC EYE DISEASE; VERNAL KERATOCONJUNCTIVITIS; TOPICAL CYCLOSPORINE; OCULAR ALLERGY; DERMATITIS; CONJUNCTIVITIS; TACROLIMUS; SURFACE; TEAR; SECRETION;
D O I
10.1016/j.jaad.2013.10.036
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Atopic keratoconjunctivitis is a chronic noninfectious inflammatory condition and is one of the most severe ophthalmic complications associated with atopic dermatitis. It requires prompt and effective treatment to prevent permanent vision loss. Complications of atopic keratoconjunctivitis include cataracts, keratoconus, infectious keratitis, blepharitis, tear dysfunction, and steroid-induced glaucoma. All treatment for atopic keratoconjunctivitis should be managed in conjunction with an ophthalmologist, and immediate referral is indicated when there is moderate to severe irritation, increased redness, discharge, or any visual symptoms. Treatment options include a combination of mast cell inhibitors, antihistamines, corticosteroids, and calcineurin inhibitors.
引用
收藏
页码:569 / 575
页数:7
相关论文
共 31 条
[1]   A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis [J].
Akpek, EK ;
Dart, JK ;
Watson, S ;
Christen, W ;
Dursun, D ;
Yoo, S ;
O'Brien, TP ;
Schein, OD ;
Gottsch, JD .
OPHTHALMOLOGY, 2004, 111 (03) :476-482
[2]   Topical tacrolimus 0.03% ointment for intractable allergic conjunctivitis: An open-label pilot study [J].
Attas-Fox, Liat ;
Barkana, Yaniv ;
Iskhakov, Vladimir ;
Rayvich, Svetlana ;
Gerber, Yariv ;
Morad, Yair ;
Avni, Isaac ;
Zadok, David .
CURRENT EYE RESEARCH, 2008, 33 (07) :545-549
[3]   Atopic Dermatitis and Keratoconjunctivitis [J].
Bielory, Brett ;
Bielory, Leonard .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2010, 30 (03) :323-+
[4]   Allergic and immunologic disorders of the eye. Part II: Ocular allergy [J].
Bielory, L .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (06) :1019-1032
[5]  
Calder VL, 1999, CLIN EXP ALLERGY, V29, P1214
[6]   Clinical grading of atopic keratoconjunctivitis [J].
Calonge, Margarita ;
Herreras, Jose M. .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 7 (05) :442-445
[7]   Randomised controlled trial of topical ciclosporin A in steroid dependent allergic conjunctivitis [J].
Daniell, M ;
Constantinou, M ;
Vu, HT ;
Taylor, HR .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2006, 90 (04) :461-464
[8]   Ocular surface disease in atopic dermatitis [J].
Dogru, M ;
Nakagawa, N ;
Tetsumoto, K ;
Katakami, C ;
Yamamoto, M .
JAPANESE JOURNAL OF OPHTHALMOLOGY, 1999, 43 (01) :53-57
[9]   Cytokine responses by conjunctival epithelial cells: An in vitro model of ocular inflammation [J].
Enriquez-de-Salamanca, Amalia ;
Calder, Virginia ;
Gao, Jianping ;
Galatowicz, Grazyna ;
Garcia-Vazquez, Carmen ;
Fernandez, Itziar ;
Stern, Michael E. ;
Diebold, Yolanda ;
Calonge, Margarita .
CYTOKINE, 2008, 44 (01) :160-167
[10]   Anti-allergic activity of cyclosporin-A metabolites and their interaction with the parent compound and FK 506 [J].
Ezeamuzie, CI .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1996, 18 (04) :263-270