Interactions of quinoline antimalarials with hematin in solution

被引：86

作者：

Egan, Timothy J. ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2006年 / 100卷 / 5-6期

关键词：

chloroquine; ferriprotoporphyrin IX; hematin; quinolines; malaria;

D O I：

10.1016/j.jinorgbio.2005.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quinoline antimalarial drugs such as chloroquine and related compounds are believed to act by targeting ferriprotoporphyrin IX (Fe(III)PPIX) in the form of hematin (H2O/HO-Fe(III)PPIX), its mu-oxo dimer ([Fe(III)PPIX](2)O) or crystalline beta-hematin ([Fe(III)PPIX](2)) in the malaria parasite. Fe(III)PPIX is formed when the parasite digests host hemoglobin during its intraerythrocytic blood stage. This has led to a number of studies on the interaction of Fe(III)PPIX with quinoline antimalarials and related compounds. This article reviews the spectroscopy, thermodynamics and structures of Fe(III)PPIX quinoline complexes in solution. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：916 / 926

页数：11

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