Treatment response of lithium augmentation in geriatric compared to non-geriatric patients with treatment-resistant depression

被引：10

作者：

Buspavanich, Pichit ^{[1
,2
]}

Behr, Joachim ^{[1
,3
]}

Stamm, Thomas ^{[1
,2
]}

Schlattmann, Peter ^{[4
]}

Bschor, Tom ^{[5
,6
]}

Richter, Christoph ^{[2
,7
]}

Hellweg, Rainer ^{[2
]}

Heinz, Andreas ^{[2
]}

Berger, Maximilian ^{[2
]}

Hindinger, Claudia ^{[1
]}

Rentzsch, Johannes ^{[1
,2
]}

de Millas, Walter ^{[8
]}

Jockers-Scheruebl, Maria-Christiane ^{[9
]}

Braeunig, Peter ^{[10
]}

Adli, Mazda ^{[2
,11
]}

Ricken, Roland ^{[2
]}

机构：

[1] Brandenburg Med Sch Theodor Fontane, Dept Psychiat Psychotherapy & Psychosomat, Campus Neuruppin, D-16816 Neuruppin, Germany

[2] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Mitre, Berlin, Germany

[3] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Res Dept Expt & Mol Psychiat, Campus Mitre, Berlin, Germany

[4] Jena Univ Hosp, Dept Stat Informat & Documentat, Jena, Germany

[5] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Med Sch, Dresden, Germany

[6] Schlosspk Klin Berlin, Dept Psychiat, Berlin, Germany

[7] Vivantes Klinikum Kaulsdorf, Dept Psychiat & Psychotherapy, Berlin, Germany

[8] Vivantes Wenckebach Klinikum Berlin, Dept Psychiat, Berlin, Germany

[9] Oberhavel Kliniken, Dept Psychiat, Hennigsdorf, Germany

[10] Vivantes Humboldt Klinikum Berlin, Dept Psychiat, Berlin, Germany

[11] Fliedner Klin Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2019年 / 251卷

关键词：

Geriatric patients; Lithium augmentation; Efficacy; Treatment-resistant depression; BIPOLAR DISORDER; OLD-AGE; PHARMACOTHERAPY;

D O I：

10.1016/j.jad.2019.03.057

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Lithium augmentation (LA) of antidepressants is an effective strategy for treatment-resistant depression (TRD). Nevertheless, it is rarely used in geriatric patients. The purpose of this study was to investigate treatment response of LA in geriatric compared to non-geriatric patients. Method: In a prospective multicenter cohort study, severity of depression was measured weekly in 167 patients with unipolar depression (n(age >= 65years) - 22; n(age<65years) - 145) at baseline and over at least four weeks of LA. Results: Geriatric patients showed a significantly better response to LA compared to non-geriatric patients (Hazard Ratio = 1.91; p=0.04). Limitations: An important limitation of our study is the lack of a control group of LA and the missing evaluation of side effects in both groups. Conclusions: This is the first study investigating the efficacy of LA for TRD in geriatric compared to non-geriatric patients. Our data suggest that LA is an effective treatment option in geriatric patients that clinicians might consider more frequently and earlier on in the course of treatment.

引用

页码：136 / 140

页数：5

共 18 条

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