Efflux of chloramphenicol by the Cm1A1 protein

被引：9

作者：

George, AM

Hall, RM

机构：

[1] Univ Technol Sydney, Fac Sci, Dept Cell & Mol Biol, Broadway, NSW 2007, Australia

[2] CSIRO Mol Sci, N Ryde, NSW 1670, Australia

来源：

FEMS MICROBIOLOGY LETTERS | 2002年 / 209卷 / 02期

关键词：

chloramphenicol efflux; Cm1A1 inner membrane protein;

D O I：

10.1111/j.1574-6968.2002.tb11133.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The cmlA1 gene cassette contains the cmlA1 gene, that confers resistance to chloramphenicol, as well as a promoter and translational attenuation signals, and expression of cmlA1 is inducible by low concentrations of chloramphenicol. The CmlA1 protein encoded by cmlA1 was localised in the inner membrane. Active efflux of chloramphenicol, additional to the endogenous efflux from Escherichia coli cells, was observed when the cmlA1 gene was present and the production of CmlA1 had been preinduced with subinhibitory concentrations of chloramphenicol. Both endogenous and CmlA1-mediated export of chloramphenicol was driven by the proton-motive force. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：209 / 213

页数：5

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