Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone

被引：17
作者：
Bhattacharya, S [1 ]
Dileep, PV [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 46期
关键词：
D O I：
10.1016/S0040-4039(99)01683-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four novel cationic lipids with oligo-oxyethylene units at various linkage regions between the pseudoglyceryl backbone and the hydrocarbon chains have been synthesized. The membrane-forming properties of these new lipids are briefly presented. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8167 / 8171
页数：5
相关论文
共 17 条
[1]   SYNTHETIC GENE-TRANSFER VECTORS [J].
BEHR, JP .
ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (05) :274-278
[2]   Synthesis of macrocyclic diacyl/dialkyl glycerols containing disulfide tether and studies of their effects upon incorporation in DPPC membranes.: Implications in the design of phospholipase A2 modulators [J].
Bhattacharya, S ;
Ghosh, S ;
Easwaran, KRK .
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (25) :9232-9242
[3]   Evidence of interlipidic ion-pairing in anion-induced DNA release from cationic amphiphile-DNA complexes. Mechanistic implications in transfection [J].
Bhattacharya, S ;
Mandal, SS .
BIOCHEMISTRY, 1998, 37 (21) :7764-7777
[4]   Synthesis and vesicle formation from hybrid bolaphile/amphiphile ion-pairs. Evidence of membrane property modulation by molecular design [J].
Bhattacharya, S ;
De, SM ;
Subramanian, M .
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (22) :7640-7651
[5]   Synthesis and vesicle formation from novel pseudoglyceryl dimeric lipids. Evidence of formation of widely different membrane organizations with exceptional thermotropic properties [J].
Bhattacharya, S ;
De, S ;
George, SK .
CHEMICAL COMMUNICATIONS, 1997, (23) :2287-2288
[6]   Modulation of vesicular properties by variation of shapes of bolaform counter ions in hybrid-ion paired surfactants [J].
Bhattacharya, S ;
De, S .
CHEMICAL COMMUNICATIONS, 1996, (11) :1283-1284
[7]   VESICLE FORMATION FROM DIMERIC SURFACTANTS THROUGH ION-PAIRING - ADJUSTMENT OF POLAR HEADGROUP SEPARATION LEADS TO CONTROL OVER VESICULAR THERMOTROPIC PROPERTIES [J].
BHATTACHARYA, S ;
DE, S .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (06) :651-652
[8]  
Deshmukh HM, 1997, NEW J CHEM, V21, P113
[9]   Synthesis of novel disulfide containing macrocyclic diacylglycerols [J].
Ghosh, S ;
Easwaran, KRK ;
Bhattacharya, S .
TETRAHEDRON LETTERS, 1996, 37 (32) :5769-5772
[10]   ALIPHATIC DIETHER ANALOGS OF GLYCERIDE-DERIVED LIPIDS .1. SYNTHESIS OF D-ALPHA,BETA-DIALKYL GLYCERYL ETHERS [J].
KATES, M ;
STANACEV, NZ ;
CHAN, TH .
BIOCHEMISTRY, 1963, 2 (02) :394-+
12