Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration

被引：2

作者：

Lee, Jung Won ^{[1
]}

Kim, Wha Young ^{[1
]}

Kim, Jeong-Hoon ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Brain Res Inst, Dept Physiol,Brain Korea Plus Project Med Sci 21, Seoul, South Korea

来源：

NEUROREPORT | 2018年 / 29卷 / 06期

关键词：

cocaine; GluA1; leptin; nucleus accumbens; SYNTHASE KINASE 3-BETA; SUBSTRATE-SPECIFICITY; INDUCED HYPERACTIVITY; AMPA RECEPTORS; REWARD; SENSITIZATION; CORE; GSK3; PLASTICITY; ADDICTION;

D O I：

10.1097/WNR.0000000000001001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microinjections of leptin in this site followed by acute administration of cocaine. Interestingly, leptin in the NAcc core significantly blocks the increase of GluA1 phosphorylation levels at serine 845 induced by acute administration of cocaine. These effects were not observed for GluA1 phosphorylation levels at serine 831. We have also found additional evidence that glycogen synthase kinase 3 may play a major role in mediating these processes.

引用

页码：483 / 487

页数：5

共 33 条

[31] Glycogen synthase kinase 3β in the nucleus accumbens core mediates cocaine-induced behavioral sensitization [J].