Meta-Selective C-H Functionalization Using a Nitrile-Based Directing Group and Cleavable Si-Tether

被引：213

作者：

Lee, Sunggi ^{[1
]}

Lee, Hyelee ^{[1
]}

Tan, Kian L. ^{[1
]}

机构：

[1] Boston Coll, Chestnut Hill, MA 02467 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 50期

关键词：

IRIDIUM-CATALYZED BORYLATION; ELECTRON-DEFICIENT ARENES; BOND FORMATION; 1,3-DISUBSTITUTED ARENES; ORTHO-HALOGENATION; OLEFINATION; ACTIVATION; COMPLEXES; PALLADIUM; SILANOL;

D O I：

10.1021/ja4107034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nitrile-based template that enables metaselective C-H bond functionalization was developed. The template is applicable to a range of substituted arenes and tolerates a variety of functional groups. The directing group uses a silicon atom for attachment, allowing for a facile introduction/deprotection strategy increasing the synthetic practicality of this template.

引用

页码：18778 / 18781

页数：4

共 67 条

[61] C-H bond activation enables the rapid construction and late-stage diversification of functional molecules [J].