Cyclization of benzyne-tethered alkyllithiums: preparation of 3-substituted benzocyclobutenes and 5-substituted tetralins

被引：17

作者：

Bailey, WF ^{[1
]}

Longstaff, SC ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(99)01434-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A five-step, one-pot preparation of isomerically pure 3-substituted benzocyclobutenes or 5-substituted tetralins in 20-40% yield from the appropriate alpha-(2-fluorophenyl)-omega-iodoalkane, involving generation and subsequent 4- or 6-exo cyclization of a benzyne-tethered alkyllithium, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6899 / 6901

页数：3

共 6 条

[1] Generation and cyclization of a benzyne-tethered alkyllithium: Preparation of 4-substituted indans [J].