Cyclization of benzyne-tethered alkyllithiums: preparation of 3-substituted benzocyclobutenes and 5-substituted tetralins

被引：17
作者：
Bailey, WF [1 ]
Longstaff, SC [1 ]
机构：
[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 38期
关键词：
D O I：
10.1016/S0040-4039(99)01434-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A five-step, one-pot preparation of isomerically pure 3-substituted benzocyclobutenes or 5-substituted tetralins in 20-40% yield from the appropriate alpha-(2-fluorophenyl)-omega-iodoalkane, involving generation and subsequent 4- or 6-exo cyclization of a benzyne-tethered alkyllithium, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：6899 / 6901
页数：3
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