Antibacterial, cytotoxicity and physical properties of laser - Silver doped hydroxyapatite layers

被引：43

作者：

Jelinek, M. ^{[1
,2
]}

Kocourek, T. ^{[1
,2
]}

Remsa, J. ^{[1
,2
]}

Weiserova, M. ^{[3
]}

Jurek, K. ^{[1
]}

Miksovsky, J. ^{[1
,2
]}

Strnad, J. ^{[4
]}

Galandakova, A. ^{[5
]}

Ulrichova, J. ^{[5
]}

机构：

[1] Inst Phys ASCR Vvi, Prague 18221 8, Czech Republic

[2] Czech Tech Univ, Fac Biomed Engn, Sitna 3105, Kladno, Czech Republic

[3] Inst Microbiol ASCR Vvi, Prague 1083 4, Czech Republic

[4] Lasak Ltd, Prague 1600 6, Czech Republic

[5] Palacky Univ, Fac Med & Dent, Olomouc 77515, Czech Republic

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 03期

关键词：

Hydroxyapatite; Silver; Thin films; PLO; Antibacterial; Cytotoxicity; SUBSTITUTED HYDROXYAPATITE; COATINGS; ROUTE; FILMS;

D O I：

10.1016/j.msec.2012.12.018

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Hydroxyapatite layers with silver doping from 0.06 at.% to 14 at.% were prepared by laser deposition. The films' physical properties such as morphology, composition, crystallinity, Young's modulus and microhardness were measured. Films were amorphous or polycrystalline in dependence on deposition temperature (from RT to 600 C). Antibacterial properties were tested using Escherichia coli and Bacillus subtilis cells. The antibacterial efficacy changed with silver doping from 4% to 100%. Cytotoxicity was studied by a direct contact test. Depending on doping and crystallinity the films were either non-toxic or mildly toxic. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1242 / 1246

页数：5

共 23 条

[1]

[Anonymous], 2005, Brock: Biology of microorganisms

[2]

APPLEYARD RK, 1954, GENETICS, V39, P440

[3]

Barbalace K.L., ELEMENT SILVER

[4]

Chambers CW, 1962, J AM WATER WORKS ASS, V54, P208, DOI DOI 10.1002/J.1551-8833.1962.TB00834.X

[5] Antibacterial and osteogenic properties hydroxyapatite coatings produced using of silver-containing a sol gel process [J].

Chen, W. ;

Oh, S. ;

Ong, A. P. ;

Oh, N. ;

Liu, Y. ;

Courtney, H. S. ;

Appleford, M. ;

Ong, J. L. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2007, 82A (04) :899-906

[6] In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating [J].

Chen, W. ;

Liu, Y. ;

Courtney, H. S. ;

Bettenga, M. ;

Agrawal, C. M. ;

Bumgardner, J. D. ;

Ong, J. L. .

BIOMATERIALS, 2006, 27 (32) :5512-5517

[7] Anti-bacterial and cytotoxic properties of plasma sprayed silver-containing HA coatings [J].

Chen, Yikai ;

Zheng, Xuebin ;

Xie, Youtao ;

Ding, Chuanxian ;

Ruan, Hongjiang ;

Fan, Cunyi .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2008, 19 (12) :3603-3609

[8] Effect of Ag-doped hydroxyapatite as a bone filler for inflamed bone defects [J].

Choi, JW ;

Cho, HM ;

Kwak, EK ;

Kwon, TG ;

Ryoo, HM ;

Jeong, YK ;

Oh, KS ;

Shin, HI .

BIOCERAMICS 16, 2004, 254-2 :47-50

[9] Anti-microbial hydroxyapatite particles synthesized by a sol-gel route [J].

Chung, RJ ;

Hsieh, MF ;

Huang, KC ;

Perng, LH ;

Chou, FI ;

Chin, TS .

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2005, 33 (02) :229-239

[10]

Clarke A.J., 1937, HDB EXPT PHARM ERGAN

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