A rendezvous before rejection: Where do T cells meet transplant antigens?

被引：50
作者：
Briscoe, DDM [1 ]
Sayegh, MH
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA
[2] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA
来源：
NATURE MEDICINE | 2002年 / 8卷 / 03期
关键词：
D O I：
10.1038/nm0302-220
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interactions between recipient T cells and donor endothelial graft cells may be an important mechanism for both acute and chronic rejection of vascularized allografts. This finding provides a starting point for investigations to develop novel ways of inducing long-lasting immunologic tolerance to donor antigens. (pages 233–239)
引用
收藏
页码：220 / 222
页数：3
相关论文
共 16 条
  • [1] THE ROLE OF INDIRECT RECOGNITION IN INITIATING REJECTION OF SKIN-GRAFTS FROM MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II-DEFICIENT MICE
    AUCHINCLOSS, H
    LEE, R
    SHEA, S
    MARKOWITZ, JS
    GRUSBY, MJ
    GLIMCHER, LH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) : 3373 - 3377
  • [2] Biedermann BC, 1998, J IMMUNOL, V161, P4679
  • [3] Interactions between T lymphocytes and endothelial cells in allograft rejection
    Briscoe, DM
    Alexander, SI
    Lichtman, AH
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (05) : 525 - 531
  • [4] Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4+ T cell alloactivation
    Denton, MD
    Geehan, CS
    Alexander, SI
    Sayegh, MH
    Briscoe, DM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (04) : 555 - 566
  • [5] EPPERSON DE, 1994, J IMMUNOL, V153, P5402
  • [6] Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection:: An alternative mechanism of allorecognition
    Kreisel, D
    Krupnick, AS
    Gelman, AE
    Engels, FH
    Popma, SH
    Krasinskas, AM
    Balsara, KR
    Szeto, WY
    Turka, LA
    Rosengard, BR
    [J]. NATURE MEDICINE, 2002, 8 (03) : 233 - 239
  • [7] LYMPHOCYTE-T ANTIGEN INTERACTIONS IN TRANSPLANT REJECTION
    KRENSKY, AM
    WEISS, A
    CRABTREE, G
    DAVIS, MM
    PARHAM, P
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (08) : 510 - 517
  • [8] Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue
    Lakkis, FG
    Arakelov, A
    Konieczny, BT
    Inoue, Y
    [J]. NATURE MEDICINE, 2000, 6 (06) : 686 - 688
  • [9] Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy
    Lee, RS
    Yamada, K
    Houser, SL
    Womer, KL
    Maloney, ME
    Rose, HS
    Sayegh, MH
    Madsen, JC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) : 3276 - 3281
  • [10] Activated murine endothelial cells have reduced immunogenicity for CD8+ T cells:: A mechanism of immunoregulation?
    Marelli-Berg, FM
    Scott, D
    Bartok, I
    Peek, E
    Dyson, J
    Lechler, RI
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (08) : 4182 - 4189
12