A rendezvous before rejection: Where do T cells meet transplant antigens?

被引：51

作者：

Briscoe, DDM ^{[1
]}

Sayegh, MH

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[2] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 03期

关键词：

D O I：

10.1038/nm0302-220

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interactions between recipient T cells and donor endothelial graft cells may be an important mechanism for both acute and chronic rejection of vascularized allografts. This finding provides a starting point for investigations to develop novel ways of inducing long-lasting immunologic tolerance to donor antigens. (pages 233–239)

引用

页码：220 / 222

页数：3

共 16 条

[1] THE ROLE OF INDIRECT RECOGNITION IN INITIATING REJECTION OF SKIN-GRAFTS FROM MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II-DEFICIENT MICE [J].

AUCHINCLOSS, H ;

LEE, R ;

SHEA, S ;

MARKOWITZ, JS ;

GRUSBY, MJ ;

GLIMCHER, LH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3373-3377

[2]

Biedermann BC, 1998, J IMMUNOL, V161, P4679

[3] Interactions between T lymphocytes and endothelial cells in allograft rejection [J].

Briscoe, DM ;

Alexander, SI ;

Lichtman, AH .

CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (05) :525-531

[4] Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4+ T cell alloactivation [J].

Denton, MD ;

Geehan, CS ;

Alexander, SI ;

Sayegh, MH ;

Briscoe, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (04) :555-566

[5]

EPPERSON DE, 1994, J IMMUNOL, V153, P5402

[6] Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection:: An alternative mechanism of allorecognition [J].

Kreisel, D ;

Krupnick, AS ;

Gelman, AE ;

Engels, FH ;

Popma, SH ;

Krasinskas, AM ;

Balsara, KR ;

Szeto, WY ;

Turka, LA ;

Rosengard, BR .

NATURE MEDICINE, 2002, 8 (03) :233-239

[7] LYMPHOCYTE-T ANTIGEN INTERACTIONS IN TRANSPLANT REJECTION [J].

KRENSKY, AM ;

WEISS, A ;

CRABTREE, G ;

DAVIS, MM ;

PARHAM, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (08) :510-517

[8] Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue [J].

Lakkis, FG ;

Arakelov, A ;

Konieczny, BT ;

Inoue, Y .

NATURE MEDICINE, 2000, 6 (06) :686-688

[9] Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy [J].

Lee, RS ;

Yamada, K ;

Houser, SL ;

Womer, KL ;

Maloney, ME ;

Rose, HS ;

Sayegh, MH ;

Madsen, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :3276-3281

[10] Activated murine endothelial cells have reduced immunogenicity for CD8+ T cells:: A mechanism of immunoregulation? [J].

Marelli-Berg, FM ;

Scott, D ;

Bartok, I ;

Peek, E ;

Dyson, J ;

Lechler, RI .

JOURNAL OF IMMUNOLOGY, 2000, 165 (08) :4182-4189

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