Genetic testing for the clinician in prostate cancer

被引：3

作者：

Lopez-Campos, Fernando ^{[1
]}

Linares-Espinos, Estefania ^{[2
,3
,4
]}

Maldonado Pijoan, Xavier ^{[5
]}

Sancho Pardo, Gemma ^{[6
]}

Morgan, Todd Mathew ^{[7
]}

Martinez-Ballesteros, Claudio ^{[3
,8
]}

Martinez-Salamanca, Juan ^{[3
,4
,8
]}

Counago, Felipe ^{[9
,10
,11
]}

机构：

[1] Hosp Univ Ramon Y Cajal, Radiat Oncol Dept, Madrid, Spain

[2] Hosp Univ La Paz, Urol Dept, Madrid, Spain

[3] Lyx Inst Urol, Urol Dept, Madrid, Spain

[4] Francisco De Vitoria Univ, Urol Dept, Madrid, Spain

[5] Hosp Univ Vall dHebron, Radiat Oncol Dept, Barcelona, Spain

[6] Hosp Santa Creu & Sant Pau, Radiat Oncol Dept, Barcelona, Spain

[7] Michigan Ctr Translat Pathol, Urol Dept, Ctr Comprehens Canc, Ctr Canc, Floor B1 Recept C, Ann Arbor, MI USA

[8] Hosp Univ Puerta De Hierro Majadahonda, Urol Dept, Majadahonda 28222, Spain

[9] Hosp Univ Quiron Salud Madrid, Radiat Oncol Dept, Madrid, Spain

[10] Hosp La Luz, Madrid, Spain

[11] Univ Europea Madrid, Madrid, Spain

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2020年 / 20卷 / 09期

关键词：

Biomarkers; gene panels; genetic counseling; genetic testing; germline mutation; CYCLE PROGRESSION SCORE; CIRCULATING TUMOR-CELLS; RISK STRATIFICATION; BRCA MUTATIONS; EXOSOMAL RNA; VALIDATION; BIOPSY; MEN; ABIRATERONE; MULTICENTER;

D O I：

10.1080/14737159.2020.1816170

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Introduction Prostate cancer (PCa) is one of the most common cancers worldwide and a leading cause of cancer-related mortality. Although the diagnosis and treatment of prostate cancer has improved substantially in recent years, new molecular biomarkers are needed to further prolong survival and improve the quality of life in these patients. Areas covered This review analyzes the current evidence for prognostic and predictive molecular biomarkers that can be applied across different clinical scenarios, ranging from localized disease to metastatic castration-resistant PCa, with a particular emphasis on the biomarkers likely to become available in routine clinical practice in the near future. Expert opinion There is a growing need for molecular testing to identify the most indolent types of prostate cancer to help optimize treatment strategies and spare treatment in these patients when possible. Current trends in the treatment of prostate cancer underscore the unmet clinical need for biomarkers to improve decision-making in a challenging clinical setting.

引用

页码：933 / 946

页数：14

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