2-triazenopyrroles: synthesis and biological activity

被引：19

作者：

Diana, P

Barraja, P

Lauria, A

Almerico, AM

Cirrincione, G

Loi, AG

Musiu, C

Pani, A

La Colla, P

Marongiu, ME

机构：

[1] Univ Palermo, Ist Farmacochim, I-90123 Palermo, Italy

[2] Univ Cagliari, Dipartimento Biol Sperimentale, Sez Microbiol, I-09124 Cagliari, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 34卷 / 04期

关键词：

2-triazenopyrroles; synthesis; cytotoxic activity; antifungal activity;

D O I：

10.1016/S0223-5234(99)80085-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Triazenopyrroles were synthesized by coupling the corresponding 2-diazopyrroles with secondary amines and tested for antiproliferative, antifungal, antiviral and antibacterial activities. Derivative 9m was the most cytotoxic, showing, against leukaemia, lymphoma and carcinoma cell lines, IC50 3.9-21 mu M and inhibited Cox-B2 and VSV with EC50 10 mu M. Derivative 9j, instead, was active against C. albicans with a selectivity index higher than that of miconazole. (C) Elsevier, Paris.

引用

页码：353 / 360

页数：8

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