Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment

被引：5

作者：

Jinushi, Masahisa ^{[1
]}

机构：

[1] Hokkaido Univ, Res Ctr Infect Associated Canc, Inst Med Genet, Sapporo, Hokkaido, Japan

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 09期

关键词：

dendritic cells; HMGB1; innate immunity; nucleic acids; TIM-3; INFLAMMATION; RECEPTORS;

D O I：

10.4161/onci.21681

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy.

引用

页码：1632 / 1634

页数：3

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