Thermosensitive polyion complex micelles prepared by self-assembly of two oppositely charged diblock copolymers

被引：13

作者：

He, Pan ^{[1
,2
]}

Zhao, Chang-wen ^{[1
,2
]}

Xiao, Chun-sheng ^{[1
,2
]}

Tang, Zhao-hui ^{[1
]}

Chen, Xue-si ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

CHINESE JOURNAL OF POLYMER SCIENCE | 2013年 / 31卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Polyion complex; Micelles; Thermosensitivity; Poly(amino acid)s; BLOCK-COPOLYMERS; SHELL;

D O I：

10.1007/s10118-013-1226-7

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polyion complex (PIC) micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers, poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) and poly(N-isopropylacrylamide)-b-poly(L-lysine). Their controlled synthesis was achieved via the ring opening polymerization of N-carboxyanhydrides (NCA), gamma-benzyloxycarbonyl-L-lysine (Lys(Z)-NCA) or gamma-benzyl-L-glutamate (BLG-NCA) with amino-terminated poly(N-isopropylacrylamide) macroinitiator and the subsequent deprotection reaction. The formation of PIC micelles was confirmed by dynamic light scattering and transmission electron microscopy. Turbidimetric characterization suggested that the formed PIC micelles had a concentration-dependent thermosensitivity and their phase transition behaviors could be easily adjusted either by the block length of coplymers or the concentration of micelles.

引用

页码：318 / 324

页数：7

共 16 条

[1] Synthesis and characterization of poly(ethylene glycol)-b-poly (L-lactide)-b-poly(L-glutamic acid) triblock copolymer [J].