Metal-free Synthesis of 2,4,6-Trisubstituted Pyrimidines using α,β-Unsaturated Ketones and Benzamidine via Tandem Annulation-Oxidation Pathway

被引：0

作者：

Vadagaonkar, Kamlesh S. ^{[1
]}

Kalmode, Hanuman P. ^{[1
]}

Murugan, Kaliyappan ^{[1
,2
]}

Chaskar, Atul C. ^{[1
,3
]}

机构：

[1] Inst Chem Technol, Dept Dyestuff Technol, Bombay 400019, Maharashtra, India

[2] Natl Taiwan Univ, Taipei 10617, Taiwan

[3] Univ Mumbai, Natl Ctr Nanosci & Nanotechnol, Bombay 400098, Maharashtra, India

来源：

LETTERS IN ORGANIC CHEMISTRY | 2015年 / 12卷 / 07期

关键词：

Benzamidine; Metal-free synthesis; Triethyl amine; Tandem [3+3] annulation-oxidation pathway; alpha; beta-Unsaturated ketones; FISCHER INDOLE SYNTHESIS; SOLID-PHASE SYNTHESIS; ONE-POT SYNTHESIS; SUBSTITUTED PYRIMIDINES; ANTIMALARIAL ACTIVITIES; PLASMODIUM-FALCIPARUM; CONVENIENT SYNTHESIS; COORDINATION ARRAYS; HIGHLY EFFICIENT; DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem metal-free synthesis of partly and fully substituted pyrimidines has been accomplished from alpha,beta-unsaturated ketones and benzamidine in presence of triethyl amine. The reaction proceeds via [3+3] annulation-oxidation sequence and the protocol has been found successful for the synthesis of a wide range of pyrimidine derivatives.

引用

页码：447 / 458

页数：12

共 81 条

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