Investigation of Fullerene Exposure of Breast Cancer Cells by Time-Gated Scanning Microwave Microscopy

被引：21

作者：

Farina, M. ^{[1
]}

Piacenza, F. ^{[2
]}

De Angelis, F. ^{[1
]}

Mencarelli, D. ^{[1
]}

Morini, A. ^{[1
]}

Venanzoni, G. ^{[1
]}

Pietrangelo, T. ^{[3
]}

Malavolta, M. ^{[2
]}

Basso, A. ^{[2
]}

Provinciali, M. ^{[2
]}

Hwang, J. C. M. ^{[4
]}

Jin, X. ^{[4
]}

Di Donato, A. ^{[1
]}

机构：

[1] Univ Politecn Marche, Dipartimento Ingn Informaz, I-60131 Ancona, Italy

[2] INRCA Ancona, I-60127 Ancona, Italy

[3] Univ G DAnnunzio, Dipartimento Neurosci, Imaging & Sci Clin, I-66100 Chieti, Italy

[4] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA

来源：

IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES | 2016年 / 64卷 / 12期

关键词：

Biological cells; microwave imaging; nanoparticles; reflectometry; scanning probe microscopy; C-60; DNA;

D O I：

10.1109/TMTT.2016.2623312

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Nanoparticles are receiving increasing attention as carriers of active drugs or biochemical signals. Among them, fullerene C-60 is particularly attractive since its cage structure helps it to carry other molecules and its lipophilicity helps it to penetrate through a cell membrane. This paper explores the potential of time-gated broadband near-field scanning microwave microscopy for detecting fullerene inside Michigan Cancer Foundation-7 breast cancer cells. It demonstrates measurement of relative variation of electromagnetic properties across the sample surface, while explaining the difficulty for measurement of absolute electromagnetic properties. The results are compared with scanning capacitance microscopy, atomic force microscopy, and scanning tunneling microscopy performed on the same samples.

引用

页码：4823 / 4831

页数：9

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