Cervical Human Papillomavirus Infection and Shedding of Human Immunodeficiency Virus in Cervicovaginal Fluids: a Cross-Sectional Study

被引：3

作者：

Fornabaio, Chiara ^{[1
,2
]}

Carvalho, Anna C. C. ^{[1
,2
]}

Lillo, Flavia ^{[3
]}

Fiore, Jose R. ^{[4
]}

Bergamaschi, Viviana ^{[1
,2
]}

Bigoni, Sara ^{[1
,2
]}

Puzzi, Petra R. ^{[1
,2
]}

Cristini, Graziella ^{[1
,2
]}

Comelli, Mario ^{[5
]}

Parisi, Maria R. ^{[6
]}

Matteelli, Alberto ^{[1
,2
]}

机构：

[1] Spedali Civili Hosp, Inst Infect & Trop Dis, Brescia, Italy

[2] Univ Brescia, Brescia, Italy

[3] Hosp Santa Corona, Clin Pathol & Microbiol Lab, Pietra Ligure, Savona, Italy

[4] Univ Foggia, Dept Infect Dis, Foggia, Italy

[5] Univ Pavia, Dept Hlth Sci, I-27100 Pavia, Italy

[6] Hosp San Raffaele, Dept Infect Dis, I-20132 Milan, Italy

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2012年 / 61卷 / 01期

关键词：

cervical HPV; cervicovaginal HIV; HIV shedding; STI; ANTIRETROVIRAL DRUG CONCENTRATIONS; FEMALE GENITAL-TRACT; NUCLEIC-ACIDS; HIV-1; RNA; WOMEN; SECRETIONS; TYPE-1; TRANSMISSION; NEOPLASIA; THERAPY;

D O I：

10.1097/QAI.0b013e31826327a0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the association between human papillomavirus cervical infection and HIV shedding in cervicovaginal lavage fluid (CVL), studying 89 HIV-infected women recruited at the Department of Infectious Diseases of Brescia (Italy). HIV shedding in CVL was found in a similar proportion of women with (30%; 21/70) and without (31.6%; 6/19) cervical human papillomavirus infection. A statistically significant correlation was found between HIV viral load in serum and CVL among the 27 women with detectable HIV in CVL (r = 0.4; P = 0.04). However, women on highly active antiretroviral therapy were more likely to have detectable HIV-RNA in CVL despite negative viremia (80% vs. 8%; P < 0.005).

引用

页码：78 / 82

页数：5

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