Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

被引：21

作者：

Lee, Wei Li ^{[1
]}

Wee, Peixin ^{[1
]}

Nugraha, Chandra ^{[1
]}

Loo, Say Chye Joachim ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2013年 / 1卷 / 08期

基金：

英国医学研究理事会;

关键词：

RIBOFLAVIN-CONTAINING MICROBALLOONS; IN-VIVO EVALUATION; DELIVERY-SYSTEM; VITRO; MICROSPHERES; FENOFIBRATE; FORMULATION; ABSORPTION; METFORMIN;

D O I：

10.1039/c2tb00495j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/ water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.

引用

页码：1090 / 1095

页数：6

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