Outcomes inN3Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection

被引：7

作者：

Boros, Angela ^{[1
]}

Blanchard, Pierre ^{[1
,2
]}

Dade, Arlette ^{[3
]}

Gorphe, Philippe ^{[3
]}

Breuskin, Ingrid ^{[3
]}

Even, Caroline ^{[3
]}

Nguyen, France ^{[1
]}

Deutsch, Eric ^{[1
,2
,4
]}

Bidault, Francois ^{[5
]}

Janot, Francois ^{[3
]}

Temam, Stephane ^{[3
]}

Mirghani, Haitham ^{[3
]}

Tao, Yungan ^{[1
,2
,4
]}

机构：

[1] Gustave Roussy Canc Campus, Dept Radiat Oncol, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[2] Univ Paris Sud, Le Kremlin Bicetre, France

[3] Gustave Roussy Canc Campus, Dept Head & Neck Oncol, Villejuif, France

[4] INSERM 1030 Mol Radiotherapy, Villejuif, France

[5] Gustave Roussy Canc Campus, Dept Radiol, Villejuif, France

来源：

LARYNGOSCOPE | 2021年 / 131卷 / 03期

关键词：

Head and neck cancer; N3; neck dissection; chemoradiotherapy; CONCOMITANT CHEMOTHERAPY; ADVANCED HEAD; CANCER; RADIOTHERAPY; CHEMORADIOTHERAPY; N3;

D O I：

10.1002/lary.28893

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0-14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%,P < .001), and PFS (P < .001). Regardless of neck node size, UFND improved survival (P= .001 for <= 7 cm andP= .004 for > 7 cm). Conclusion UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence 2BLaryngoscope, 2020

引用

页码：E844 / E850

页数：7

共 20 条

[1] Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): A comprehensive analysis by tumour site
Blanchard, Pierre
Baujat, Bertrand
Holostenco, Victoria
Bourredjem, Abderrahmane
Baey, Charlotte
Bourhis, Jean
Pignon, Jean-Pierre
[J]. RADIOTHERAPY AND ONCOLOGY, 2011, 100 (01) : 33 - 40
[2] Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial
Bourhis, Jean
Sire, Christian
Graff, Pierre
Gregoire, Vincent
Maingon, Philippe
Calais, Gilles
Gery, Bernard
Martin, Laurent
Alfonsi, Marc
Desprez, Patrick
Pignon, Thierry
Bardet, Etienne
Rives, Michel
Geoffrois, Lionel
Daly-Schveitzer, Nicolas
Sen, Sok
Tuchais, Claude
Dupuis, Olivier
Guerif, Stephane
Lapeyre, Michel
Favrel, Veronique
Hamoir, Marc
Lusinchi, Antoine
Temam, Stephane
Pinna, Antonella
Tao, Yun Gan
Blanchard, Pierre
Auperin, Anne
[J]. LANCET ONCOLOGY, 2012, 13 (02) : 145 - 153
[3] Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma
Calais, G
Alfonsi, M
Bardet, E
Sire, C
Germain, T
Bergerot, P
Rhein, B
Tortochaux, J
Oudinot, P
Bertrand, P
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (24) : 2081 - 2086
[4] p16 Protein Expression and Human Papillomavirus Status As Prognostic Biomarkers of Nonoropharyngeal Head and Neck Squamous Cell Carcinoma
Chung, Christine H.
Zhang, Qiang
Kong, Christina S.
Harris, Jonathan
Fertig, Elana J.
Harari, Paul M.
Wang, Dian
Redmond, Kevin P.
Shenouda, George
Trotti, Andy
Raben, David
Gillison, Maura L.
Jordan, Richard C.
Quynh-Thu Le
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (35) : 3930 - U212
[5] Up-front neck dissection followed by definitive (chemo)-radiotherapy in head and neck squamous cell carcinoma: Rationale, complications, toxicity rates, and oncological outcomes - A systematic review
Elicin, Olgun
Nisa, Lluis
Dal Pra, Alan
Bojaxhiu, Beat
Caversaccio, Marco
Schmucking, Michael
Aebersold, Daniel M.
Giger, Roland
[J]. RADIOTHERAPY AND ONCOLOGY, 2016, 119 (02) : 185 - 193
[6] Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Gregoire, V.
Lefebvre, J. -L.
Licitra, L.
Felip, E.
[J]. ANNALS OF ONCOLOGY, 2010, 21 : v184 - v186
[7] Extensive Neck Node Metastases (N3) in Head and Neck Squamous Carcinoma: Is Radical Treatment Warranted?
Jones, Andrew S.
Goodyear, Paul W.
Ghosh, Samit
Husband, David
Helliwell, Tim R.
Jones, Terry M.
[J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2011, 144 (01) : 29 - 35
[8] DeCIDE and PARADIGM: nails in the coffin of induction chemotherapy in head and neck squamous cell carcinoma?
Loo, S. W.
Geropantas, K.
Roques, T. W.
[J]. CLINICAL & TRANSLATIONAL ONCOLOGY, 2013, 15 (03) : 248 - 251
[9] Head and Neck Cancers-Major Changes in the American Joint Committee on Cancer Eighth Edition Cancer Staging Manual
Lydiatt, William M.
Patel, Snehal G.
O'Sullivan, Brian
Brandwein, Margaret S.
Ridge, John A.
Migliacci, Jocelyn C.
Loomis, Ashley M.
Shah, Jatin P.
[J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (02) : 122 - 137
[10] PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer
Mehanna, Hisham
Wong, Wai-Lup
McConkey, Christopher C.
Rahman, Joy K.
Robinson, Max
Hartley, Andrew G. J.
Nutting, Christopher
Powell, Ned
Al-Booz, Hoda
Robinson, Martin
Junor, Elizabeth
Rizwanullah, Mohammed
von Zeidler, Sandra V.
Wieshmann, Hulya
Hulme, Claire
Smith, Alison F.
Hall, Peter
Dunn, Janet
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (15) : 1444 - 1454

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