On the ancestral recruitment of metalloproteinases into the venom of snakes

被引：42

作者：

Casewell, Nicholas R. ^{[1
]}

机构：

[1] Univ Liverpool, Liverpool Sch Trop Med, Alistair Reid Venom Res Unit, Liverpool L3 5QA, Merseyside, England

来源：

TOXICON | 2012年 / 60卷 / 04期

关键词：

Molecular evolution; Ancestral reconstruction; Toxin; Serpentes; Venom; Metalloproteinase; SVMP; ADAM; MULTIPLE SEQUENCE ALIGNMENT; ADAPTIVE EVOLUTION; DISINTEGRIN-LIKE; GENE-EXPRESSION; CYSTEINE-RICH; MATRIX; FAMILY; NEOFUNCTIONALIZATION; DIVERSITY; SELECTION;

D O I：

10.1016/j.toxicon.2012.02.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：449 / 454

页数：6

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