High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB

被引：57

作者：

Shankar, Eswar ^{[1
,2
]}

Vykhovanets, Eugene V. ^{[1
,2
]}

Vykhovanets, Olena V. ^{[1
,2
]}

MacLennan, Gregory T. ^{[3
]}

Singh, Rajesh ^{[5
]}

Bhaskaran, Natarajan ^{[1
,2
]}

Shukla, Sanjeev ^{[1
,2
]}

Gupta, Sanjay ^{[1
,2
,4
]}

机构：

[1] Case Western Reserve Univ, Dept Urol, Cleveland, OH 44106 USA

[2] Univ Hosp Case Med Ctr, Inst Urol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Dept Nutr, Cleveland, OH 44106 USA

[5] Morehouse Sch Med, Dept Microbiol Biochem & Immunol, Atlanta, GA 30310 USA

来源：

PROSTATE | 2012年 / 72卷 / 03期

关键词：

inflammation; high-fat diet; prostate; Stat-3; NF-?B; KINASE-C-EPSILON; INSULIN-RESISTANCE; SIGNALING PATHWAY; PROTEIN; CANCER; PHOSPHORYLATION; INTERLEUKIN-6; SERINE-536; P65; TRANSCRIPTION-3;

D O I：

10.1002/pros.21425

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Signal transducer and activator of transcription (Stat)-3 and nuclear factor-kappa B (NF-?B) are important signaling pathways constitutively activated during inflammation. We previously reported that high-fat diet (HFD) intake induces oxidative stress in the prostate through elevated expression of NADPH oxidase subunits causing NF-?B activation. We sought to determine whether Stat-3 is involved in the activation of NF-?B in the prostate as a result of HFD feeding, leading to inflammation.

引用

页码：233 / 243

页数：11

共 41 条

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