HIPEC with oxaliplatin for colorectal peritoneal metastasis: The end of the road?

被引：82
作者：
Ceelen, Wim [1 ,2 ]
机构：
[1] Ghent Univ Hosp, Dept GI Surg, C Heymanslaan 10, B-9000 Ghent, Belgium
[2] Ghent Univ Hosp, CRIG, B-9000 Ghent, Belgium
来源：
EJSO | 2019年 / 45卷 / 03期
关键词：
Colorectal; HIPEC; Peritoneal; Metastasis; HYPERTHERMIC INTRAPERITONEAL CHEMOPERFUSION; IN-VITRO; CYTOREDUCTIVE SURGERY; DIALYSIS FLUIDS; CANCER; CHEMOTHERAPY; SURVIVAL; CYTOTOXICITY; CISPLATIN;
D O I：
10.1016/j.ejso.2018.10.542
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In patients with colorectal peritoneal metastases (PM), the use of cytoreductive surgery (CRS) and HIPEC with oxaliplatin (OX) is increasingly used. The results of the recently reported randomized Prodige 7 trial failed to show a difference in overall survival between patients undergoing CRS alone versus CRS combined with HIPEC using high dose OX. The trial was not designed or powered, however, to detect a potentially clinically meaningful benefit in locoregional disease control. Here, I address some potential explanations for the lack of benefit in the Prodige 7 trial, including OX efficacy issues, adverse effects of intraperitoneal high dose glucose, and potential drawbacks of the use of hyperthermia. (C) 2018 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
引用
收藏
页码：400 / 402
页数：3
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