Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

被引：14

作者：

He, Jun ^{[1
]}

Tang, Xue-Mei ^{[1
]}

Liu, Ting-Ting ^{[1
]}

Peng, Feng ^{[1
]}

Zhou, Qing ^{[1
]}

Liu, Li-Wei ^{[1
]}

He, Ming ^{[1
]}

Xue, Wei ^{[1
]}

机构：

[1] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

来源：

CHEMICAL PAPERS | 2021年 / 75卷 / 03期

关键词：

Myricetin derivative; Sulfonylpiperazine; Antibacterial activity; Concentration for 50% of maximal effect; Scanning electron microscope; ANTIFUNGAL ACTIVITY; DESIGN; SILVER;

D O I：

10.1007/s11696-020-01363-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity againstXanthomonas oryzaepv. oryzae(Xoo),Xanthomonas axonopodispv. citri(Xac) andRalstonia solanacearum(Rs). Among them, compounds4mand4prevealed excellent antibacterial activities against Rs with a concentration for 50% of maximal effect (EC50) value of 4 and 4 mu g/mL, which were better than the control drugs bismerthiazol (13 mu g/mL) and thiodiazole-copper (185 mu g/mL). As observed using scanning electron microscope (SEM), these compounds act by causing folding and deformation of the bacterial surface, resulting in incomplete bacterial structure, so as to achieve the goal of bacteriostasis. The myricetin derivatives synthesized are expected to guide the research direction of new antibacterial agents.

引用

页码：1021 / 1027

页数：7

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