Asymmetric Hydrogenation of Ketones with H2 and Ruthenium Catalysts Containing Chiral Tetradentate S2N2 Ligands

被引：52

作者：

Patchett, Ruth ^{[1
]}

Magpantay, Iris ^{[1
]}

Saudan, Lionel ^{[1
]}

Schotes, Christoph ^{[2
]}

Mezzetti, Antonio ^{[2
]}

Santoro, Francesco ^{[1
]}

机构：

[1] Firmenich Co, Corp R&D Div, CH-1211 Geneva 8, Switzerland

[2] ETH, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 39期

关键词：

alcohols; asymmetric hydrogenation; homogeneous catalysis; ruthenium; S ligands; ENANTIOSELECTIVE HYDROGENATION; STEREOSELECTIVE HYDROGENATION; SELECTIVE HYDROGENATION; COMPLEXES; PHOSPHORUS; SULFUR;

D O I：

10.1002/anie.201304844

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Getting more for less: In the presence of H2 and a base, air- and moisture-tolerant RuII complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 106:1. The reactions tolerate scale-up and can be carried out with almost no solvent. A base-free method is available for base-sensitive substrates. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10352 / 10355

页数：4

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