The integration of cell and chemical biology in protein folding

被引：28
作者：
Kelly, JW
Balch, WE
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92130 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92130 USA
[3] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92130 USA
[4] Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92130 USA
来源：
NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 05期
关键词：
D O I：
10.1038/nchembio0506-224
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic cells are specialized, interdependent functional units of complex tissues that are composed of metabolically integrated systems defined by chemically distinct organelles that operate as reaction vessels. It is now clear that the small-molecule and polymer-based composition of these organelles plays a crucial role in generating and maintaining protein folds and functions through the systems chemistry of the local environments.
引用
收藏
页码：224 / 227
页数：4
相关论文
共 36 条
[1]   Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells [J].
Albanèse, V ;
Yam, AYW ;
Baughman, J ;
Parnot, C ;
Frydman, J .
CELL, 2006, 124 (01) :75-88
[2]   Cell biology - Protein sorting by directed maturation of Golgi compartments [J].
Allan, RB ;
Balch, WE .
SCIENCE, 1999, 285 (5424) :63-66
[3]   Integration of endoplasmic reticulum signaling in health and disease [J].
Aridor, M ;
Balch, WE .
NATURE MEDICINE, 1999, 5 (07) :745-751
[4]   The mechanisms of vesicle budding and fusion [J].
Bonifacino, JS ;
Glick, BS .
CELL, 2004, 116 (02) :153-166
[5]   Enzyme replacement for lysosomal diseases [J].
Brady, RO .
ANNUAL REVIEW OF MEDICINE, 2006, 57 :283-296
[6]   The genetics of the amyloidoses [J].
Buxbaum, JN ;
Tagoe, CE .
ANNUAL REVIEW OF MEDICINE, 2000, 51 :543-569
[7]  
COHEN E, 2006, IN PRESS SCIENCE
[8]   Regulated portals of entry into the cell [J].
Conner, SD ;
Schmid, SL .
NATURE, 2003, 422 (6927) :37-44
[9]   Functional amyloid formation within mammalian tissue [J].
Fowler, DM ;
Koulov, AV ;
Alory-Jost, C ;
Marks, MS ;
Balch, WE ;
Kelly, JW .
PLOS BIOLOGY, 2006, 4 (01) :100-107
[10]   The ABC protein turned chloride channel whose failure causes cystic fibrosis [J].
Gadsby, DC ;
Vergani, P ;
Csanády, L .
NATURE, 2006, 440 (7083) :477-483
1234