Precursor lesions to prostatic adenocarcinoma

被引：60

作者：

Epstein, Jonathan I. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ Hosp, Dept Urol & Oncol, Baltimore, MD 21231 USA

来源：

VIRCHOWS ARCHIV | 2009年 / 454卷 / 01期

关键词：

Prostatic intraepithelial neoplasia; Intraductal carcinoma of the prostate; ATYPICAL ADENOMATOUS HYPERPLASIA; METHYLACYL-COA RACEMASE; INTRAEPITHELIAL NEOPLASIA PIN; BASAL-CELL HYPERPLASIA; NEEDLE-BIOPSY; REPEAT BIOPSY; INTRADUCTAL CARCINOMA; CLINICAL-SIGNIFICANCE; CANCER-DETECTION; ENDOMETRIOID FEATURES;

D O I：

10.1007/s00428-008-0707-5

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

High-grade prostatic intraepithelial neoplasia (PIN) is the one well-documented precursor to adenocarcinoma of the prostate. This review article defines both low- and high-grade PIN. Unusual variants of high-grade PIN are illustrated. Benign lesions that may be confused with high-grade PIN, including central zone histology, clear cell cribriform hyperplasia, and basal cell hyperplasia are described and illustrated. High-grade PIN is also differentiated from invasive acinar (usual) and ductal adenocarcinoma. The incidence of high-grade PIN, its relationship to carcinoma (including molecular findings), and risk of cancer on rebiopsy are covered in detail. Finally, intraductal carcinoma of the prostate, a controversial entity, is discussed and differentiated from high-grade PIN.

引用

页码：1 / 16

页数：16

共 91 条

[1] Predictors of prostate cancer on extended biopsy in patients with high-grade prostatic intraepithelial neoplasia: a multivariate analysis model [J].