Protein Kinase D was involved in vascular remodeling in spontaneously hypertensive rats

被引：5

作者：

Geng, Jing ^{[1
]}

Zhao, Zhuo ^{[2
]}

Yang, Le ^{[1
]}

Zhang, Mingwei ^{[1
]}

Liu, Xiangjuan ^{[3
,4
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China

[2] Jinan Cent Hosp, Dept Cardiol, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, Jinan, Shandong, Peoples R China

[4] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Hlth, Jinan, Shandong, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2019年 / 41卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Protein Kinase D; vascular remodeling; hypertension; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; D ACTIVATION; VEGF; INFLAMMATION; PHOSPHORYLATION; VULNERABILITY; ANGIOGENESIS; ALDOSTERONE; CONTRIBUTES;

D O I：

10.1080/10641963.2018.1469647

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was designed to determine the role of PKD in vascular remodeling (VR) in Spontaneously hypertensive rats (SHRs). Increased SBP, VR and PKD activation were prominent in SHRs. The SBP has a positive correlation with the activation of PKD in SHRs. The ratio of media to lumen (MT/LD), volume fraction of collagen (VFC), hydroxyproline, IL-6, TNF-alpha and nitrotyrosine content were significantly related to the activated PKD. It may be concluded that PKD plays a central role in VR, and the mechanism may be related to its regulation of hypertrophy, fibrosis, inflammation and oxidative stress.

引用

页码：299 / 306

页数：8

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