Protein Kinase D was involved in vascular remodeling in spontaneously hypertensive rats

被引：4
作者：
Geng, Jing [1 ]
Zhao, Zhuo [2 ]
Yang, Le [1 ]
Zhang, Mingwei [1 ]
Liu, Xiangjuan [3 ,4 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China
[2] Jinan Cent Hosp, Dept Cardiol, Jinan, Shandong, Peoples R China
[3] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, Jinan, Shandong, Peoples R China
[4] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Hlth, Jinan, Shandong, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2019年 / 41卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Protein Kinase D; vascular remodeling; hypertension; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; D ACTIVATION; VEGF; INFLAMMATION; PHOSPHORYLATION; VULNERABILITY; ANGIOGENESIS; ALDOSTERONE; CONTRIBUTES;
D O I：
10.1080/10641963.2018.1469647
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study was designed to determine the role of PKD in vascular remodeling (VR) in Spontaneously hypertensive rats (SHRs). Increased SBP, VR and PKD activation were prominent in SHRs. The SBP has a positive correlation with the activation of PKD in SHRs. The ratio of media to lumen (MT/LD), volume fraction of collagen (VFC), hydroxyproline, IL-6, TNF-alpha and nitrotyrosine content were significantly related to the activated PKD. It may be concluded that PKD plays a central role in VR, and the mechanism may be related to its regulation of hypertrophy, fibrosis, inflammation and oxidative stress.
引用
收藏
页码：299 / 306
页数：8
相关论文
共 36 条
  • [1] Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
    Argaw, Azeb Tadesse
    Asp, Linnea
    Zhang, Jingya
    Navrazhina, Kristina
    Trinh Pham
    Mariani, John N.
    Mahase, Sean
    Dutta, Dipankar J.
    Seto, Jeremy
    Kramer, Elisabeth G.
    Ferrara, Napoleone
    Sofroniew, Michael V.
    John, Gareth R.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (07) : 2454 - 2468
  • [2] ECM remodeling in hypertensive heart disease
    Berk, Bradford C.
    Fujiwara, Keigi
    Lehoux, Stephanie
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (03) : 568 - 575
  • [3] Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-κB
    Chiu, Terence T.
    Leung, Wai Yin
    Moyer, Mary Pat
    Strieter, Robert M.
    Rozengurt, Enrique
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 292 (02): : C767 - C777
  • [4] VEGF and depression: A comprehensive assessment of clinical data
    Clark-Raymond, Anne
    Halaris, Angelos
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 2013, 47 (08) : 1080 - 1087
  • [5] VEGF-mediated inflammation precedes angiogenesis in adult brain
    Croll, SD
    Ransohoff, RM
    Cai, N
    Zhang, Q
    Martin, FJ
    Wei, T
    Kasselman, LJ
    Kintner, J
    Murphy, AJ
    Yancopoulos, GD
    Wiegand, SJ
    [J]. EXPERIMENTAL NEUROLOGY, 2004, 187 (02) : 388 - 402
  • [6] A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation
    Doeppler, Heike
    Storz, Peter
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (44) : 31873 - 31881
  • [7] The effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damage
    Esrefoglu, Mukaddes
    Gul, Mehmet
    Ates, Burhan
    Erdogan, Ali
    [J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2011, 25 (05) : 580 - 590
  • [8] Requirement of protein kinase D1 for pathological cardiac remodeling
    Fielitz, Jens
    Kim, Mi-Sung
    Shelton, John M.
    Qi, Xiaoxia
    Hill, Joseph A.
    Richardson, James A.
    Bassel-Duby, Rhonda
    Olson, Eric N.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (08) : 3059 - 3063
  • [9] Hypertrophic response to angiotensin II is mediated by protein kinase D-extracellular signal-regulated kinase 5 pathway in human aortic smooth muscle cells
    Geng, Jing
    Zhao, Zhuo
    Kang, Weiqiang
    Wang, Wei
    Liu, Guanghui
    Sun, Yingying
    Zhang, Yun
    Ge, Zhiming
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 388 (03) : 517 - 522
  • [10] Reactive Oxygen Species in Pathogenesis of Atherosclerosis
    Goncharov, Nikolay V.
    Avdonin, Pavel V.
    Nadeev, Alexander D.
    Zharkikh, Irina L.
    Jenkins, Richard O.
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (09) : 1134 - 1146
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