Transgenic goats in the world pharmaceutical industry of the 21st century

被引：8

作者：

Goldman, IL ^{[1
]}

Kadulin, SG

Razin, SV

机构：

[1] Russian Acad Sci, Inst Gene Biol, Moscow 117334, Russia

[2] Univ Oslo, Ctr Med Sci, Moscow 117334, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2002年 / 38卷 / 01期

关键词：

D O I：

10.1023/A:1013785725040

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In many developed countries, isolation of human pharmaceutical proteins from milk of genetically modified animals is currently a priority. One of the first commercial pharmaceuticals obtained from the milk of transgenic goats, an anticoagulant antithrombin III, developed by Genzyme Transgenic Corporation, an American biotechnological company, will appear on the pharmaceutical market in the nearest future. In this review, we discuss the role of fundamental science in the development of this field of the pharmaceutical industry.

引用

页码：1 / 14

页数：14

共 101 条

[1] Characterization of the bovine kappa-Casein gene promoter [J].

Adachi, T ;

Ahn, JY ;

Yamamoto, K ;

Aoki, N ;

Nakamura, R ;

Matsuda, T .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1996, 60 (12) :1937-1940

[2] HUMAN GROWTH-HORMONE (HGH) SECRETION IN MILK OF GOATS AFTER DIRECT TRANSFER OF THE HGH GENE INTO THE MAMMARY-GLAND BY USING REPLICATION-DEFECTIVE RETROVIRUS VECTORS [J].

ARCHER, JS ;

KENNAN, WS ;

GOULD, MN ;

BREMEL, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :6840-6844

[3] HIGH-LEVEL EXPRESSION OF BIOLOGICALLY-ACTIVE HUMAN ALPHA-1-ANTITRYPSIN IN THE MILK OF TRANSGENIC MICE [J].

ARCHIBALD, AL ;

MCCLENAGHAN, M ;

HORNSEY, V ;

SIMONS, JP ;

CLARK, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) :5178-5182

[4] Production of goats by somatic cell nuclear transfer [J].

Baguisi, A ;

Behboodi, E ;

Melican, DT ;

Pollock, JS ;

Destrempes, MM ;

Cammuso, C ;

Williams, JL ;

Nims, SD ;

Porter, CA ;

Midura, P ;

Palacios, MJ ;

Ayres, SL ;

Denniston, RS ;

Hayes, ML ;

Ziomek, CA ;

Meade, HM ;

Godke, RA ;

Gavin, WG ;

Overström, EW ;

Echelard, Y .

NATURE BIOTECHNOLOGY, 1999, 17 (05) :456-461

[5]

Bashkeev E. D., 1989, Zootekhniya, P56

[6] Recombinant human acid α-glucosidase:: high level production in mouse milk, biochemical characteristics, correction of enzyme deficiency in GSDII KO mice [J].

Bijvoet, AGA ;

Kroos, MA ;

Pieper, FR ;

Van der Vliet, M ;

De Boer, HA ;

Van der Ploeg, AT ;

Verbeet, MP ;

Reuser, AJJ .

HUMAN MOLECULAR GENETICS, 1998, 7 (11) :1815-1824

[7]

Bleck GT, 1998, J ANIM SCI, V76, P3072

[8] VARIATION IN EXPRESSION OF A BOVINE ALPHA-LACTALBUMIN TRANSGENE IN MILK OF TRANSGENIC MICE [J].

BLECK, GT ;

BREMEL, RD .

JOURNAL OF DAIRY SCIENCE, 1994, 77 (07) :1897-1904

[9]

Bode J, 1995, INT REV CYTOL, V162A, P389

[10] Regulation of the chicken lysozyme locus in transgenic mice [J].

Bonifer, C ;

Huber, MC ;

Faust, N ;

Sippel, AE .

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 1996, 6 (2-3) :285-297

← 1 2 3 4 5 6 7 8 9 10 →