Dual Ligand-Enabled Nondirected C-H Cyanation of Arenes

被引：64

作者：

Chen, Hao ^{[1
]}

Mondal, Arup ^{[1
]}

Wedi, Philipp ^{[1
]}

van Gemmeren, Manuel ^{[1
,2
]}

机构：

[1] Max Planck Inst Chem Energy Convers, Stiftstr 34-36, D-45470 Mulheim, Germany

[2] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany

来源：

ACS CATALYSIS | 2019年 / 9卷 / 03期

关键词：

C-H activation; cyanation; dual-ligand catalysis; palladium catalysis; nitriles; PALLADIUM-CATALYZED CYANATION; ELECTRON-DEFICIENT ARENES; AMINO-ACID LIGANDS; BOND CYANATION; ARYL HALIDES; ACTIVATION; FUNCTIONALIZATION; N; N-DIMETHYLFORMAMIDE; OLEFINATION; HETEROARENES;

D O I：

10.1021/acscatal.8b04639

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Aromatic nitriles are key structural units in organic chemistry and, therefore, highly attractive targets for C-H activation. Herein, the development of an arene-limited, nondirected C-H cyanation based on the use of two cooperatively acting commercially available ligands is reported. The reaction enables the cyanation of arenes by C-H activation in the absence of directing groups and is therefore complementary to established approaches.

引用

页码：1979 / 1984

页数：11

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