Nanoplasmonic Au nanodot arrays as an SERS substrate for biomedical applications

被引：39

作者：

Jung, Gyeong Bok ^{[1
,2
]}

Bae, Young Min ^{[3
]}

Lee, Young Ju ^{[1
,2
]}

Ryu, Seong Hee ^{[5
]}

Park, Hun-Kuk ^{[1
,2
,4
]}

机构：

[1] Kyung Hee Univ, Coll Med, Dept Biomed Engn, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Med, Healthcare Ind Res Inst, Seoul 130701, South Korea

[3] Korea Electrotechnol Res Inst, Gyeonggi Do 426910, South Korea

[4] Kyung Hee Univ, Program Med Engn, Seoul 130701, South Korea

[5] Kyung Hee Univ, Sch Dent, Dept Orthodont, Seoul 130701, South Korea

来源：

APPLIED SURFACE SCIENCE | 2013年 / 282卷

关键词：

Surface enhanced Raman scattering; Gold nanodot array; Anodized aluminum oxide; ENHANCED RAMAN-SCATTERING; POROUS ALUMINA MASK; ANODIC ALUMINA; RHODAMINE-B; SPECTROSCOPY; DNA; DIAGNOSTICS; STABILITY; LABEL; TOOL;

D O I：

10.1016/j.apsusc.2013.05.093

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We demonstrate the preparation of gold nanodot arrays with nanoplasmonic structures for a surface enhanced Raman scattering (SERS) active substrate. The substrate was based on an anodized aluminum oxide template with various gold layer thicknesses. The activity of gold nanodot arrays as substrates was experimentally verified using Rhodamine B as an analyte. The experimental data showed increased enhancement as a function of Au layer thickness. The nanoplasmonic gold nanodot array structure presented in this study will allow for simple, low-cost fabrication of highly reproducible and uniform SERS substrate over a large area without the requirement for high resolution lithography. We demonstrated that gold nanodot arrays can be used as a platform for label-free RNA detection using SERS. This result could lead to the development of a nucleic acid diagnostic tool for biomedical applications using SERS detection. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：161 / 164

页数：4

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