Prognostic and Predictive Immunohistochemistry-Based Biomarkers in Cancer and Immunotherapy

被引：23

作者：

Rizk, Emanuelle M. ^{[1
]}

Gartrell, Robyn D. ^{[1
]}

Barker, Luke W. ^{[2
]}

Esancy, Camden L. ^{[1
]}

Finkel, Grace G. ^{[2
]}

Bordbar, Darius D. ^{[2
]}

Saenger, Yvonne M. ^{[1
]}

机构：

[1] Columbia Univ, Irving Med Ctr, Dept Med, 650 West 168th St,Black Bldg 8-816, New York, NY 10032 USA

[2] Columbia Univ, Irving Med Ctr, Coll Phys & Surg, 650 West 168th St,Black Bldg 8-816, New York, NY 10032 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 02期

关键词：

Immunotherapy; Predictive and prognostic biomarkers; Checkpoint inhibition; Immunohistochemistry; TUMOR-INFILTRATING LYMPHOCYTES; BREAST-CANCER; STAGE-III; PD-1; BLOCKADE; IMMUNE CELLS; T-CELLS; ANTIBODY; IPILIMUMAB; EXPRESSION; MELANOMA;

D O I：

10.1016/j.hoc.2018.12.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunotherapy has drastically improved the prognosis of many patients with cancer, but it can also lead to severe immune-related adverse events. Biomarkers, which are molecular markers that indicate a patient's disease outcome or a patient's response to treatment, are therefore crucial to helping clinicians weigh the potential benefits of immunotherapy against its potential toxicities. Immunohistochemistry (IHC) has thus far been a powerful technique for discovery and use of biomarkers such as CD8(+) tumor infiltrating lymphocytes. However, IHC has limited reproducibility. Thus, if more IHC-based biomarkers are to reach the clinic, refinement of the technique using multiplexing or automation is key.

引用

页码：291 / +

页数：11

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