Stromal-derived conditioned media activates STAT3 via JAK2 and TYK2 and results in de novo resistance to Nilotinib

被引：0
|
作者：
Nair, Rajesh R. [1 ]
Tolentino, Joel H. [1 ]
Argilagos, Raul F. [1 ]
Zhang, Ling [1 ]
Pinilla-Ibarz, Javier [1 ]
Hazlehurst, Lori A. [1 ]
机构：
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
来源：
CANCER RESEARCH | 2011年 / 71卷
关键词：
D O I：
10.1158/1538-7445.AM2011-5033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
5033
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2, STAT1, and STAT3
    Nagata, Y
    Todokoro, K
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 221 (03) : 785 - 789
  • [2] BCR-ABL activates STAT3 via Jak2 and MEK pathways.
    Coppo, P
    Wittner, M
    De Mas, V
    Guillier, M
    Bonnet, ML
    Lacout, C
    Vainchenker, W
    Turhan, AG
    BLOOD, 2003, 102 (11) : 588A - 588A
  • [3] IL-6 Activates the Mineralocorticoid Receptor via the JAK2/STAT3 Pathway
    Moyer, Hayley Catherine
    Krishnamurthy, Ashwini
    Mallick, Rickta
    Hoover, Robert S.
    Wynne, Brandi Michele
    FASEB JOURNAL, 2018, 32 (01):
  • [4] COLONY-STIMULATING FACTOR 1-INDUCED STAT1 AND STAT3 ACTIVATION IS ACCOMPANIED BY PHOSPHORYLATION OF TYK2 IN MACROPHAGES AND TYK2 AND JAK1 IN FIBROBLASTS
    NOVAK, U
    HARPUR, AG
    PARADISO, L
    KANAGASUNDARAM, V
    JAWOROWSKI, A
    WILKS, AF
    HAMILTON, JA
    BLOOD, 1995, 86 (08) : 2948 - 2956
  • [5] Claudin-9 enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling
    Liu, Hongyu
    Wang, Min
    Liang, Na
    Guan, Lianyue
    TURKISH JOURNAL OF GASTROENTEROLOGY, 2019, 30 (08): : 722 - 731
  • [6] The JAK kinase Tyk2 and the Signal Transducer and Activator of Transcription 3 (Stat3) are required for Brown Adipose Tissue Differentiation
    Larner, Andrew Charles
    Derecka, Marta
    Gornicka, Agnieszka
    Szczepanek, Karol
    Morgan, Magdalena
    Raje, Vidisha
    Sisler, Jennifer
    Keller, Susanna
    FASEB JOURNAL, 2012, 26
  • [7] Activation of dendritic cells via inhibition of Jak2/STAT3 signaling
    Nefedova, Y
    Cheng, PY
    Gilkes, D
    Blaskovich, M
    Beg, AA
    Sebti, SM
    Gabrilovich, DI
    JOURNAL OF IMMUNOLOGY, 2005, 175 (07): : 4338 - 4346
  • [8] THROMBOPOIETIN, C-MPL LIGAND, INDUCES TYROSINE PHOSPHORYLATION OF TYK2, JAK2, AND STAT3, AND ENHANCES AGONISTS-INDUCED AGGREGATION IN PLATELETS IN-VITRO
    EZUMI, Y
    TAKAYAMA, H
    OKUMA, M
    FEBS LETTERS, 1995, 374 (01) : 48 - 52
  • [9] Investigation of genetic susceptibility to nonspecific digestive disorder between TYK2, JAK1, and STAT3 genes in rabbits
    Fu, Lu
    Zhao, Ming-De
    Chen, Shi-Yi
    Jia, Xian-Bo
    Lai, Song-Jia
    LIVESTOCK SCIENCE, 2015, 181 : 137 - 142
  • [10] CHOLINERGIC AGONISTS SUPPRESS ENDOTHELIAL CELL ACTIVATION VIA JAK2/STAT3
    Metz, C. N.
    Sherry, B.
    Chatterjee, P. K.
    SHOCK, 2009, 31 : 19 - 19
12345